ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015
Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance.
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Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76citing papers in PubMed
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76 citing papers in PubMed, 146 citations in OpenAlex.
- Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects.Scientific reports · 2016Trial
- Exploring the role of alpha-tocopherol in pain and inflammation: interplay with TRPV1, PKA, and PKC pathways.The Korean journal of pain · 2026Article
- Capsaicin for cardiometabolic syndrome: multitarget mechanisms and therapeutic potential.Frontiers in nutrition · 2026Review
- The Role of TRPV1 in Type 1 Diabetes.Biology · 2025Review
- PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1.iScience · 2024Article
- Roles of TRP and PIEZO receptors in autoimmune diseases.Expert reviews in molecular medicine · 2024Review
- Role of TRP Channels in Metabolism-Related Diseases.International journal of molecular sciences · 2024Review
- Fat-free mass is associated with exercise pressor responses, but not cold pressor responses, in humans: influence of maximal voluntary contraction.Frontiers in sports and active living · 2024Article
- The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice.Frontiers in endocrinology · 2024Article
- The metabolic and functional roles of sensory nerves in adipose tissues.Nature metabolism · 2023Review
- Review
- Diallyl disulfide alleviates hypercholesterolemia induced by a western diet by suppressing endoplasmic reticulum stress in apolipoprotein E-deficient mice.BMC complementary medicine and therapies · 2023Article
- The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population.Microbiome · 2023Article
- Progress in the Structural Basis of thermoTRP Channel Polymodal Gating.International journal of molecular sciences · 2023Review
- Capsaicin supplementation prevents western diet-induced hyperleptinemia by reducing endoplasmic reticulum stress in apolipoprotein E-deficient mice.Food & nutrition research · 2023Article
- Dietary Capsaicin: A Spicy Way to Improve Cardio-Metabolic Health?Biomolecules · 2022Review
- Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes.International journal of molecular sciences · 2022Article
- Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine.Nature biomedical engineering · 2022Article
- Review
- TRPV1 Suppressed NLRP3 Through Regulating Autophagy in Microglia After Ischemia-Reperfusion Injury.Journal of molecular neuroscience : MN · 2022Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 1 institution in 1 country.
Eunjung Lee*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Dae Young Jung*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Jong Hun Kim*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Payal R Patel*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Xiaodi Hu*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Yongjin Lee*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Yoshihiro Azuma*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Hsun-Fan Wang*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Nicholas Tsitsilianos*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Umber Shafiq*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Jung Yeon Kwon*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Hyong Joo Lee*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Ki Won Lee*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea jason.kim@umassmed.edu kiwon@snu.ac.kr.
Jason K Kim*Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, USA; World Class University Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea; Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam, Republic of Korea; and Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea jason.kim@umassmed.edu kiwon@snu.ac.kr.
University of Massachusetts Chan Medical School · US
Funding
Systems Biology of Insulin ResistanceR24DK090963 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2011 to 2014
$8.4MUMass Mouse Metabolic Phenotyping CenterU24DK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2011 to 2015
$2.1MInterleukin-10 and Regulation of Skeletal Muscle Insulin ActionR01DK080756 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2008 to 2012
$1.6MNIDDK NIH HHS R01 DK080756NIDDK NIH HHS R01-DK080756NIDDK NIH HHS R24 DK090963NIDDK NIH HHS R24-DK090963NIDDK NIH HHS U24 DK093000NIDDK NIH HHS U24-DK093000
Abstract
Insulin resistance is a major characteristic of obesity and type 2 diabetes, but the underlying mechanism is unclear. Recent studies have shown a metabolic role of capsaicin that may be mediated via the transient receptor potential vanilloid type-1 (TRPV1) channel. In this study, TRPV1 knockout (KO) and wild-type (WT) mice (as controls) were fed a high-fat diet (HFD), and metabolic studies were performed to measure insulin and leptin action. The TRPV1 KO mice became more obese than the WT mice after HFD, partly attributed to altered energy balance and leptin resistance in the KO mice. The hyperinsulinemic-euglycemic clamp experiment showed that the TRPV1 KO mice were more insulin resistant after HFD because of the ∼40% reduction in glucose metabolism in the white and brown adipose tissue, compared with that in the WT mice. Leptin treatment failed to suppress food intake, and leptin-mediated hypothalamic signal transducer and activator of transcription (STAT)-3 activity was blunted in the TRPV1 KO mice. We also found that the TRPV1 KO mice were more obese and insulin resistant than the WT mice at 9 mo of age. Taken together, these results indicate that lacking TRPV1 exacerbates the obesity and insulin resistance associated with an HFD and aging, and our findings further suggest that TRPV1 has a major role in regulating glucose metabolism and hypothalamic leptin's effects in obesity.
Indexed as
Adipose Tissue, BrownAgingAnimalsCells, CulturedDiabetes Mellitus, Type 2Dietary FatsDiet, High-FatEnergy MetabolismGlucoseInsulinInsulin ResistanceLeptinMaleMiceMice, Inbred C57BLObesityDietary FatsGlucoseInsulinLeptinTRPV1 protein, mouseTRPV Cation Channelsagingcapsaicinglucose metabolismhyperinsulinemic-euglycemic clamp
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.