Evidence map›Paper›PMID 25888551›Full record

ReviewBrain : a journal of neurology2015

Parkinson's disease dementia: a neural networks perspective.

James Gratwicke, Marjan Jahanshahi, Thomas Foltynie

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain : a journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04571112 (Multi-targets, Single-lead GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment), which is not on this map. Cited by 187 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04571112 nacompletednot on this mapstarted 2017, after this paper: background citation

Multi-targets, Single-lead GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment

TypeinterventionalSponsorUniversity of TorontoRan2017 to 2021Enrolled6ConditionsParkinson Disease, Memory DisordersArmsNBM stimulation using the Vercise device (Boston Scientific, Marlborough, Massachusetts, US)
3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James GratwickeSobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK, WC1N 3BG j.gratwicke@ucl.ac.uk.
Marjan JahanshahiSobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK, WC1N 3BG.
Thomas FoltynieSobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK, WC1N 3BG.

Funding

Department of Health
6 · The paper itself

Abstract

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more prevalent in the future. However, current treatments only give modest symptomatic benefit at best. New treatments are slow in development because unlike the pathological processes underlying the motor deficits of Parkinson's disease, the neural mechanisms underlying the dementing process and its associated cognitive deficits are still poorly understood. Recent insights from neuroscience research have begun to unravel the heterogeneous involvement of several distinct neural networks underlying the cognitive deficits in Parkinson's disease dementia, and their modulation by both dopaminergic and non-dopaminergic transmitter systems in the brain. In this review we collate emerging evidence regarding these distinct brain networks to give a novel perspective on the pathological mechanisms underlying Parkinson's disease dementia, and discuss how this may offer new therapeutic opportunities.

Indexed as

Adrenergic NeuronsBrainBrain WavesCholinergic NeuronsDementiaDopaminergic NeuronsHumansModels, NeurologicalNerve DegenerationNeural PathwaysParkinson DiseaseVisual Perceptionacetylcholinedementiadopamineneural networksParkinson’s disease

Identifiers

PMID25888551
PMCPMC4614131

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.