Evidence map›Paper›PMID 25888518›Full record

ArticleItalian journal of pediatrics2015

Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection.

Fabio Natale, Bianca Bizzarri, Veronica Cardi, Aurelia Gaeta, Paola Villani, Giuseppina Liuzzi, Mario De Curtis

Open access · goldAbstract readCase Reports
In one paragraph

Article in Italian journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fabio NataleDepartment of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. fab.natale@libero.it.
Bianca BizzarriDepartment of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. bizzarribianca@gmail.com.
Veronica CardiDepartment of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. veronica.cardi@gmail.com.
Aurelia GaetaLaboratory of Virology, Department of Public Health and Infectious Diseases, "La Sapienza" University of Rome, Rome, Italy. aurelia.gaeta@uniroma1.it.
Paola VillaniDepartment of Pharmacology, IRCCS Policlinico S. Matteo, Pavia, Italy. paolavillani2003@libero.it.
Giuseppina LiuzziI.N.M.I. Lazzaro Spallanzani, Rome, Italy. giuseppina.liuzzi@inmi.it.
Mario De CurtisDepartment of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. mario.decurtis@uniroma1.it.
Sapienza University of Rome · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant's cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.

Indexed as

AdultAntiviral AgentsCytomegalovirus InfectionsDNA, ViralFemaleGanciclovirHumansInfant, NewbornPregnancyPregnancy Complications, InfectiousValganciclovirAntiviral AgentsDNA, ViralGanciclovirValganciclovir

Identifiers

PMID25888518
PMCPMC4389576
OpenAlexW1992736476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.