ArticleAmerican journal of physiology. Heart and circulatory physiology2015
Type 2 diabetes, obesity, and sex difference affect the fate of glucose in the human heart.
Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Effects of Age and Sex on Systemic Inflammation and Cardiometabolic Function in Individuals With Type 2 Diabetes.Journal of the American Heart Association · 2025Article
- Glucose metabolic dysregulation of diabetes and Its role in atrial fibrillation pathogenesis.Frontiers in cardiovascular medicine · 2025Review
- The genetic and observational nexus between diabetes and arthritis: a national health survey and mendelian randomization analysis.Nutrition & diabetes · 2024Article
- The role of acetylation in obesity-induced cardiac metabolic alterations.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024Review
- Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart.JACC. Basic to translational science · 2023Article
- Western Diet Causes Heart Failure With Reduced Ejection Fraction and Metabolic Shifts After Diastolic Dysfunction and Novel Cardiac Lipid Derangements.JACC. Basic to translational science · 2023Article
- Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets.Cardiovascular research · 2023Review
- Guidelines on models of diabetic heart disease.American journal of physiology. Heart and circulatory physiology · 2022Review
- Combined metabolomic and transcriptomic profiling approaches reveal the cardiac response to high-fat diet.iScience · 2022Article
- Diabetic cardiomyopathy: Clinical phenotype and practice.Frontiers in endocrinology · 2022Review
- Covariables of Myocardial Function in Women and Men with Increased Body Mass Index.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Article
- Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol.JCI insight · 2020Article
- Mechanistic Causes of Reduced Cardiorespiratory Fitness in Type 2 Diabetes.Journal of the Endocrine Society · 2020Review
- Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy.Circulation research · 2020Review
- Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women.The Proceedings of the Nutrition Society · 2020Review
- Bioenergetic functions in subpopulations of heart mitochondria are preserved in a non-obese type 2 diabetes rat model (Goto-Kakizaki).Scientific reports · 2020Article
- Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using HyperpolarizedCirculation research · 2020Article
- Myocardial Energetics in Heart Failure With Preserved Ejection Fraction.Circulation. Heart failure · 2019Article
- Is it time to reassess the role of myocardial metabolic modulation for the treatment of heart failure?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Type 2 diabetes, obesity, and sex difference affect myocardial glucose uptake and utilization. However, their effect on the intramyocellular fate of glucose in humans has been unknown. How the heart uses glucose is important, because it affects energy production and oxygen efficiency, which in turn affect heart function and adaptability. We hypothesized that type 2 diabetes, sex difference, and obesity affect myocardial glucose oxidation, glycolysis, and glycogen production. In a first-in-human study, we measured intramyocardiocellular glucose metabolism from time-activity curves generated from previously obtained positron emission tomography scans of 110 subjects in 3 groups: nonobese, obese, and diabetes. Group and sex difference interacted in the prediction of all glucose uptake, utilization, and metabolism rates. Group independently predicted fractional glucose uptake and its components: glycolysis, glycogen deposition, and glucose oxidation rates. Sex difference predicted glycolysis rates. However, there were fewer differences in glucose metabolism between diabetic patients and others when plasma glucose levels were included in the modeling. The potentially detrimental effects of obesity and diabetes on myocardial glucose metabolism are more pronounced in men than women. This sex difference dimorphism needs to be taken into account in the design, trials, and application of metabolic modulator therapy. Slightly higher plasma glucose levels improve depressed glucose oxidation and glycogen deposition rates in diabetic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.