Observational studyNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2015
Arteriovenous fistula creation may slow estimated glomerular filtration rate trajectory.
Observational study in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Vascular Access in Older Adults Approaching Kidney Failure: Is There a Single Right Time?Kidney360 · 2026Article
- Evaluating the impact of Arteriovenous Fistula (AVF) creation on kidney function.Journal of nephrology · 2025Observational
- Vascular Access Management After Kidney Transplantation Position Paper on Behalf of the Vascular Access Society and the European Kidney Transplant Association.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Impact of arteriovenous fistula formation on trajectory of kidney function decline: a target trial emulation.Clinical kidney journal · 2024Article
- Cardiac implications of upper-arm arteriovenous fistulas: A case series.The journal of vascular access · 2023Article
- Lung Congestion Severity in Kidney Transplant Recipients Is Not Affected by Arteriovenous Fistula Function.Journal of clinical medicine · 2022Article
- Flow reduction of a high-flow arteriovenous fistula in a hemodialysis patient reveals changes in natriuretic and renin-angiotensin system hormones of relevance for kidney function.Physiological reports · 2021Article
- Suboptimal dialysis initiation is associated with comorbidities and uraemia progression rate but not with estimated glomerular filtration rate.Clinical kidney journal · 2021Article
- Vascular Access Perspectives in Patients After Kidney Transplantation.Frontiers in surgery · 2021Article
- Impact of Arteriovenous fistula creation on estimated glomerular filtration rate decline in Predialysis patients.BMC nephrology · 2019Article
- Response to "The Effect of Arteriovenous Fistula on Hard Endpoints Should be Observed Prospectively in Both CKD and Non-CKD Patients".American journal of hypertension · 2019Article
- Effect of Arteriovenous Fistula Creation on Systolic and Diastolic Blood Pressure in Patients With Pre-dialysis Advanced Chronic Kidney Disease.American journal of hypertension · 2019Article
- Effect of arteriovenous access closure and timing on kidney function in kidney transplant recipients.PloS one · 2019Article
- 10-Year Renal Function Trajectories in Community-Dwelling Older Adults: Exploring the Risk Factors for Different Patterns.Journal of clinical medicine · 2018Article
- Observational
- Controversies in the management of the haemodialysis-related arteriovenous fistula following kidney transplantation.Clinical kidney journal · 2018Article
- Decline of kidney function during the pre-dialysis period in chronic kidney disease patients: a systematic review and meta-analysis.Clinical epidemiology · 2018Article
- Association between vascular access creation and deceleration of estimated glomerular filtration rate decline in late-stage chronic kidney disease patients transitioning to end-stage renal disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Arteriovenous fistula as a nephroprotective intervention in advanced CKD: scientific discovery and explanation, and the evaluation of interventions.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe practice the timely placement of an arteriovenous fistula (AVF) in patients facing chronic hemodialysis. We have anecdotally observed after AVF creation that there appears to be a slowing of the decline in kidney function as measured by the estimated glomerular filtration rate (eGFR). There are physiologically plausible explanations as to how an AVF might alter kidney function, but this clinical observation has been attributed to improved compliance and/or other practices. The present retrospective observational analysis was performed to assess the possibility that a successfully created AVF could be associated with the slowing of the eGFR trajectory.
methodsWe identified 123 patients between 2005 and 2010 with at least two eGFR determinations for 2 years before and up to 2 years after AVF creation. Inclusion eligibility was that the fistula was maturing by the nephrologists' initial post-creation examination. Termination events were death, starting dialysis or transplantation. Each subject served as their own control for the pre- and post-AVF-creation eGFR measurements.
resultsSubjects' median age was 68 years and 56% were diabetic. The rate of change of the eGFR for the 2 years prior to AVF creation was -5.9 mL/min/year (95% CI: -5.3, -6.5) and after AVF creation -0.5 mL/min/year (95% CI: -1.1, 0.1) (interaction (P < 0.001).
conclusionsA functioning AVF may be associated with a slowing of the eGFR decline. Agreeing to timely AVF creation selects patients in an otherwise typical population and other confounders have not yet been eliminated. To do so a thorough prospective observational study is indicated.
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