ArticleBMC genetics2015
Comparative mapping combined with homology-based cloning of the rice genome reveals candidate genes for grain zinc and iron concentration in maize.
Article in BMC genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Meta-QTL s and haplotypes for efficient zinc biofortification of rice.The plant genome · 2023Pooled it
- Pooled it
- Meta-QTLs, ortho-meta-QTLs and candidate genes for grain yield and associated traits in wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- Finger Millet: A Genetic Resource for Calcium and Iron Biofortification in Staple Crops.Molecular nutrition & food research · 2026Review
- Genomic prediction and QTL analysis for grain Zn content and yield inJournal of plant biochemistry and biotechnology · 2024Article
- Quantitative trait loci and candidate genes for iron and zinc bio-fortification in genetically diverse germplasm of maize (Heliyon · 2022Review
- Identification of Zinc Efficiency-Associated Loci (International journal of molecular sciences · 2022Article
- Meta-QTLs, ortho-MetaQTLs and candidate genes for grain Fe and Zn contents in wheat (Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- High-resolution genome-wide association study pinpoints metal transporter and chelator genes involved in the genetic control of element levels in maize grain.G3 (Bethesda, Md.) · 2021Article
- Identification and Analysis of Zinc Efficiency-Associated Loci in Maize.Frontiers in plant science · 2021Article
- Identification of SNP Markers Associated with Iron and Zinc Concentrations in Cicer Seeds.Current genomics · 2020Article
- Article
- Mapping of resistance to corn borers in a MAGIC population of maize.BMC plant biology · 2019Article
- Genome-wide identification ofPeerJ · 2019Article
- Mapping Genetic Loci for Quantitative Traits of Golden Shell Color, Mineral Element Contents, and Growth-Related Traits in Pacific Oyster (Crassostrea gigas).Marine biotechnology (New York, N.Y.) · 2018Article
- Identification and validation of genomic regions influencing kernel zinc and iron in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Genome-wide association analysis of lead accumulation in maize.Molecular genetics and genomics : MGG · 2018Article
- Genome-wide association analysis and QTL mapping reveal the genetic control of cadmium accumulation in maize leaf.BMC genomics · 2018Article
- Maize Combined Insect Resistance Genomic Regions and Their Co-localization With Cell Wall Constituents Revealed by Tissue-Specific QTL Meta-Analyses.Frontiers in plant science · 2018Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrain zinc and iron concentration is a complex trait that is controlled by quantitative trait loci (QTL) and is important for maintaining body health. Despite the substantial effort that has been put into identifying QTL for grain zinc and iron concentration, the integration of independent QTL is useful for understanding the genetic foundation of traits. The number of QTL for grain zinc and iron concentration is relatively low in a single species. Therefore, combined analysis of different genomes may help overcome this challenge.
resultsAs a continuation of our work on maize, meta-analysis of QTL for grain zinc and iron concentration in rice was performed to identify meta-QTL (MQTL). Based on MQTL in rice and maize, comparative mapping combined with homology-based cloning was performed to identify candidate genes for grain zinc and iron concentration in maize. In total, 22 MQTL in rice, 4 syntenic MQTL-related regions, and 3 MQTL-containing candidate genes in maize (ortho-mMQTL) were detected. Two maize orthologs of rice, GRMZM2G366919 and GRMZM2G178190, were characterized as natural resistance-associated macrophage protein (NRAMP) genes and considered to be candidate genes. Phylogenetic analysis of NRAMP genes among maize, rice, and Arabidopsis thaliana further demonstrated that they are likely responsible for the natural variation of maize grain zinc and iron concentration.
conclusionsSyntenic MQTL-related regions and ortho-mMQTL are prime areas for future investigation as well as for marker-assisted selection breeding programs. Furthermore, the combined method using the rice genome that was used in this study can shed light on other species and help direct future quantitative trait research. In conclusion, these results help elucidate the molecular mechanism that underlies grain zinc and iron concentration in maize.
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