Observational studyCritical care (London, England)2015
High central venous saturation after cardiac surgery is associated with increased organ failure and long-term mortality: an observational cross-sectional study.
Observational study in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using the ΔvapCO2 / Cav02 Ratio as a Prognostic Marker and Predictor of Complications After Cardiac Surgery
Comparison of the Predictive and Prognostic Value of Cellular Dysoxia Markers in the Postoperative Period of Cardiac Surgery With Extracorporeal Circulation
Who cites it
18 citing papers in PubMed.
- Association between lactic acidosis and multiple organ dysfunction syndrome after cardiopulmonary bypass.PeerJ · 2024Article
- Influence of timing of Levosimendan administration on outcomes in cardiac surgery.Frontiers in cardiovascular medicine · 2023Article
- Article
- High Central Venous Pressure after Cardiac Surgery Might Depict Hemodynamic Deterioration Associated with Increased Morbidity and Mortality.Journal of clinical medicine · 2021Article
- Commentary: Taking the next step in cardiopulmonary bypass management.JTCVS techniques · 2020Article
- Improving the prognostic value of ∆PCOJournal of clinical monitoring and computing · 2020Article
- The Organ-Protective Effect of Higher Partial Pressure of Arterial Carbon Dioxide in the Normal Range for Infant Patients Undergoing Ventricular Septal Defect Repair.Pediatric cardiology · 2020Article
- Relationship of relevant factors to P(v-a)COThe Journal of international medical research · 2020Article
- Liver function after transplantation in the assessment of the coagulation system and the concept of antithrombotic therapy.Przeglad gastroenterologiczny · 2020Article
- Predictive value of ScvOHerz · 2019Article
- Peripheral measurements of venous oxygen saturation and lactate as a less invasive alternative for hemodynamic monitoring.Scandinavian journal of trauma, resuscitation and emergency medicine · 2018Observational
- [Venous saturation : Between oxygen delivery and consumption].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- Intradialytic Central Venous Oxygen Saturation is Associated with Clinical Outcomes in Hemodialysis Patients.Scientific reports · 2017Article
- Usefulness of central venous saturation as a predictor of thiamine deficiency in critically ill patients: a case report.Journal of intensive care · 2017Article
- The application of early goal directed therapy in patients during burn shock stage.International journal of burns and trauma · 2017Article
- Alleviating central venous oxygen saturation (ScvO2): a new approach of kidney protection after cardiac surgery?Critical care (London, England) · 2015Article
- Clinical classification of tissue perfusion based on the central venous oxygen saturation and the peripheral perfusion index.Critical care (London, England) · 2015Observational
- [Perioperative central venous oxygen saturation and its correlation with mortality during cardiac surgery: an observational prospective study].Brazilian journal of anesthesiology (Elsevier)Observational
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCentral venous saturation (ScvO2) monitoring has been suggested to address the issue of adequate cardiocirculatory function in the context of cardiac surgery. The aim of this study was to determine the impact of low (L) (<60%), normal (N) (60%-80%), and high (H) (>80%) ScvO2 measured on intensive care unit (ICU) admission after cardiac surgery.
methodsWe conducted a retrospective, cross-sectional, observational study at three ICUs of a university hospital department for anaesthesiology and intensive care. Electronic patient records of all adults who underwent cardiac surgery between 2006 and 2013 and available admission measurements of ScvO2 were examined. Patients were allocated to one of three groups according to first ScvO2 measurement after ICU admission: group L (<60%), group N (60%-80%), and group H (>80%). Primary end-points were in-hospital and 3-year follow-up survival.
resultsData from 4,447 patients were included in analysis. Low and high initial measurements of ScvO2 were associated with increased in-hospital mortality (L: 5.6%; N: 3.3%; H: 6.8%), 3-year follow-up mortality (L: 21.6%; N: 19.3%; H: 25.8%), incidence of post-operative haemodialysis (L: 11.5%; N: 7.8%; H: 15.3%), and prolonged hospital length of stay (L: 13 days, 9-22; N: 12 days, 9-19; H: 14 days, 9-21). After adjustment for possible confounding variables, an initial ScvO2 above 80% was associated with adjusted hazard ratios of 2.79 (95% confidence interval (CI) 1.565-4.964, P <0.001) for in-hospital survival and 1.31 (95% CI 1.033-1.672, P = 0.026) for 3-year follow-up survival.
conclusionsPatients with high ScvO2 were particularly affected by unfavourable outcomes. Advanced haemodynamic monitoring may help to identify patients with high ScvO2 who developed extraction dysfunction and to establish treatment algorithms to improve patient outcome in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.