ArticleBMC genomics2015
Genome comparison provides molecular insights into the phylogeny of the reassigned new genus Lysinibacillus.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- Identification of the Integration/Excision Module and Regulatory Elements Involved in the Mobility of IME8, an Integrative and Mobilizable Element From Mosquitocidal Lysinibacillus sphaericus.Microbial biotechnology · 2026Article
- Taxonomic Characterization, Whole-Genome Sequencing, and Cosmetic Potential ofMicroorganisms · 2025Article
- Characterization of the bacterial and fungal diversity in habitats of Corsica Island.Applied and environmental microbiology · 2025Article
- Whole-genome analysis of Lysinibacillus boronitolerans MSR1: A dairy-isolated multidrug-resistant and non-pathogenic strain.PloS one · 2025Article
- Lysinibacillus pinottii sp. nov., a novel species with anti-mosquito and anti-mollusk activity.Antonie van Leeuwenhoek · 2024Article
- Lysinibacillus spp.: an IAA-producing endospore forming-bacteria that promotes plant growth.Antonie van Leeuwenhoek · 2023Article
- Feed nutritional composition affects the intestinal microbiota and digestive enzyme activity of black soldier fly larvae.Frontiers in microbiology · 2023Article
- Characterization and heterologous expression of a novel CoApplied microbiology and biotechnology · 2022Article
- Review
- Complete Genome Sequence ofMicrobiology resource announcements · 2019Article
- Robust Demarcation of the FamilyFrontiers in microbiology · 2019Article
- The LspC3-41I restriction-modification system is the major determinant for genetic manipulations of Lysinibacillus sphaericus C3-41.BMC microbiology · 2017Article
- Staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package mecA gene.Scientific reports · 2017Article
- Genome Comparison ofJournal of genomics · 2017Article
- A genome-scale metabolic reconstruction of Lysinibacillus sphaericus unveils unexploited biotechnological potentials.PloS one · 2017Article
- Comparative genomics reveals Lysinibacillus sphaericus group comprises a novel species.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLysinibacillus sphaericus (formerly named Bacillus sphaericus) is incapable of polysaccharide utilization and some isolates produce active insecticidal proteins against mosquito larvae. Its taxonomic status was changed to the genus Lysinibacillus in 2007 with some other organisms previously regarded as members of Bacillus. However, this classification is mainly based on physiology and phenotype and there is limited genomic information to support it.
resultsIn this study, four genomes of L. sphaericus were sequenced and compared with those of 24 representative strains belonging to Lysinibacillus and Bacillus. The results show that Lysinibacillus strains are phylogenetically related based on the genome sequences and composition of core genes. Comparison of gene function indicates the major difference between Lysinibacillus and the two Bacillus species is related to metabolism and cell wall/membrane biogenesis. Although L. sphaericus mosquitocidal isolates are highly conserved, other Lysinibacillus strains display a large heterogeneity. It was observed that mosquitocidal toxin genes in L. sphaericus were in close proximity to genome islands (GIs) and mobile genetic elements (MGEs). Furthermore, different copies and varying genomic location of the GIs containing binA/binB was observed amongst the different isolates. In addition, a plasmid highly similar to pBsph, but lacking the GI containing binA/binB, was found in L. sphaericus SSII-1.
conclusionsOur results confirm the taxonomy of the new genus Lysinibacillus at the genome level and suggest a new species for mosquito-toxic L. sphaericus. Based on our findings, we hypothesize that (1) Lysinibacillus strains evolved from a common ancestor and the mosquitocidal L. sphaericus toxin genes were acquired by horizontal gene transfer (HGT), and (2) capture and loss of plasmids occurs in the population, which plays an important role in the transmission of binA/binB.
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