ReviewCritical care (London, England)2015
Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest.
Review in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Establishing an in vivo large animal model of one-lung ventilation and operative lung trauma.PloS one · 2025Article
- Inflammation, endothelial injury, and the acute respiratory distress syndrome after out-of-hospital cardiac arrest.Resuscitation plus · 2024Article
- Acute respiratory distress syndrome after in-hospital cardiac arrest.Resuscitation · 2022Article
- Pathophysiology and clinical consequences of arterial blood gases and pH after cardiac arrest.Intensive care medicine experimental · 2020Review
- Use of SOFA score in cardiac arrest research: A scoping review.Resuscitation plus · 2020Article
- Impact of Lung Compliance on Neurological Outcome in Patients with Acute Respiratory Distress Syndrome Following Out-of-Hospital Cardiac Arrest.Journal of clinical medicine · 2020Article
- Variations of Postresuscitation Lung Function after Thrombolysis Therapy in a Cardiac Arrest Porcine Model Caused by Pulmonary Thromboembolism.Chinese medical journal · 2017Article
- Hyperoxia toxicity after cardiac arrest: What is the evidence?Annals of intensive care · 2016Review
- Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update.Annals of intensive care · 2015Article
- Erratum to: Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest.Critical care (London, England) · 2015Article
Corrections and comments
- Erratum issuedErratum to: Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest.2015 · Pullalarevu, Raghevesh [corrected to Pullalarevu, Raghavesh]
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
introductionPost-cardiac arrest patients are often exposed to 100% oxygen during cardiopulmonary resuscitation and the early post-arrest period. It is unclear whether this contributes to development of pulmonary dysfunction or other patient outcomes.
methodsWe performed a retrospective cohort study including post-arrest patients who survived and were mechanically ventilated at least 24 hours after return of spontaneous circulation. Our primary exposure of interest was inspired oxygen, which we operationalized by calculating the area under the curve of the fraction of inspired oxygen (FiO₂AUC) for each patient over 24 hours. We collected baseline demographic, cardiovascular, pulmonary and cardiac arrest-specific covariates. Our main outcomes were change in the respiratory subscale of the Sequential Organ Failure Assessment score (SOFA-R) and change in dynamic pulmonary compliance from baseline to 48 hours. Secondary outcomes were survival to hospital discharge and Cerebral Performance Category at discharge.
resultsWe included 170 patients. The first partial pressure of arterial oxygen (PaO₂):FiO₂ ratio was 241 ± 137, and 85% of patients had pulmonary failure and 55% had cardiovascular failure at presentation. Higher FiO₂AUC was not associated with change in SOFA-R score or dynamic pulmonary compliance from baseline to 48 hours. However, higher FiO₂AUC was associated with decreased survival to hospital discharge and worse neurological outcomes. This was driven by a 50% decrease in survival in the highest quartile of FiO₂AUC compared to other quartiles (odds ratio for survival in the highest quartile compared to the lowest three quartiles 0.32 (95% confidence interval 0.13 to 0.79), P = 0.003).
conclusionsHigher exposure to inhaled oxygen in the first 24 hours after cardiac arrest was not associated with deterioration in gas exchange or pulmonary compliance after cardiac arrest, but was associated with decreased survival and worse neurological outcomes.
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