ReviewMolecular oncology2015
The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research.
Review in Molecular oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed.
- Lecanemab for Patients With Early Alzheimer Disease: Bayesian Analysis of a Phase 2b Dose-Finding Randomized Clinical Trial.JAMA network open · 2023Trial
- Challenges and opportunities in biomarker-driven trials: adaptive randomization.Annals of translational medicine · 2022Trial
- Trial
- Trial
- MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Trial
- A response-adaptive design of initial therapy for emergency department patients with heart failure.Contemporary clinical trials · 2017Trial
- Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer.The New England journal of medicine · 2016Trial
- Adaptive Randomization of Neratinib in Early Breast Cancer.The New England journal of medicine · 2016Trial
- Modern Clinical Trials: Seamless Designs and Master Protocols.Cancer medicine · 2026Review
- An Adaptive Biomarker-based Umbrella Trial Design Using Bayesian Latent Class Model.Statistics in biopharmaceutical research · 2026Article
- Bayesian adaptive randomization in the I-SPY2 sequential multiple assignment randomized trial.Biometrics · 2026Article
- Review
- Clinical applications of immunogenomics in hepatocellular carcinoma.Clinical and molecular hepatology · 2026Review
- Statistical innovations in clinical trial design with a focus on drug combinations, factorials, and other multiple therapy issues.The journal of prevention of Alzheimer's disease · 2025Article
- Blood and urine-based biomarkers in prostate cancer: Current advances, clinical applications, and future directions.The journal of liquid biopsy · 2025Review
- Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025Article
- Adaptive Bayesian Clinical Trials: The Past, Present, and Future of Clinical Research.Journal of clinical medicine · 2025Article
- Use of Bayesian approaches in oncology clinical trials: A cross-sectional analysis.Frontiers in pharmacology · 2025Article
- An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types.Pain reports · 2024Article
- Advice to the FDA to Improve Its Proposed Guidelines to Rationalize Clinical Trials by Restricting Placebo Control, Preventing Low-Powered Studies, and Disallowing Studies Where Bioavailability Is Not Proven.Pharmaceuticals (Basel, Switzerland) · 2024Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platform trials and basket trials. Both are attempting to merge clinical research and clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.