ReviewScandinavian journal of trauma, resuscitation and emergency medicine2015
Transfusion therapy in paediatric trauma patients: a review of the literature.
Review in Scandinavian journal of trauma, resuscitation and emergency medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 58 citations in OpenAlex.
- The Role of Viscoelastic Testing in Assessing Hemostasis: A Challenge to Standard Laboratory Assays?Journal of clinical medicine · 2024Review
- Polytrauma in Children—Epidemiology, Acute Diagnostic Evaluation, and Treatment.Deutsches Arzteblatt international · 2024Review
- Canadian tertiary care pediatric massive hemorrhage protocols: a survey and comprehensive national review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Rotational thromboelastometry in children presenting to an Australian major trauma centre: A retrospective cohort study.Emergency medicine Australasia : EMA · 2022Observational
- Fibrinogen Early In Severe paediatric Trauma studY (FEISTY junior): protocol for a randomised controlled trial.BMJ open · 2022Article
- Changes in transfusion and fluid therapy practices in severely injured children: an analysis of 5118 children from the TraumaRegister DGU®.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- It is time for TEG in pediatric trauma: unveiling meaningful alterations in children who undergo massive transfusion.Pediatric surgery international · 2021Article
- Successful ROTEM-guided transfusion therapy in a case of rural paediatric trauma.BMJ case reports · 2019Article
- Effect and clinical value of coagulation test on adverse reactions of blood transfusion in patients with major bleeding in ectopic pregnancy.Experimental and therapeutic medicine · 2018Article
- Low Plasma ADAMTS13 Activity Is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Paediatric Trauma.Thrombosis and haemostasis · 2018Article
- Paediatric trauma resuscitation: an update.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemorrhage is a leading cause of death in paediatric trauma patients. Predefined massive transfusion protocols (MTP) have the potential to significantly reduce mortality by treating haemorrhagic shock and coagulopathy, in adhering to the principles of haemostatic resuscitation with rapid administration of balanced ratios of packed red blood cells (RBC), fresh frozen plasma (FFP) and platelets (PLT).Because of their substantial physiological reserve, initial vital signs may not be good predictors of early haemorrhage in paediatric patients. Determining the triggers for MTP activation in paediatric trauma patients is challenging, and the optimal blood product ratio that will increase survival in massively bleeding paediatric trauma patients has yet to be determined. To date, only a few small descriptive studies and case reports have investigated the use of predefined MTP in paediatric trauma patients.MTP with increased FFP or PLT to RBC ratios combined with viscoelastic haemostatic assay (VHA) guided haemostatic resuscitation have not yet been tested in paediatric populations but based on results from adult trauma patients, this therapeutic approach seems promising.Considering the high prevalence of early coagulopathy in paediatric trauma patients, immediate identification and implementation of VHA-directed treatment of traumatic coagulopathy could ensure faster haemostasis and thereby, potentially, reduce bleeding as well as the total transfusion requirements and further improve outcome in paediatric trauma patients. Prospective randomized trials investigating this therapeutic approach in paediatric trauma patients are highly warranted.
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