ArticleBMC surgery2015
Long-term prognosis of surgical treatment for early ampullary cancers and implications for local ampullectomy.
Article in BMC surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Safety and efficacy of endoscopic papillectomy for duodenal papillary adenomas: A single-center retrospective study.World journal of gastrointestinal surgery · 2026Article
- Safety of intrabiliary radiofrequency ablation in cases of residual and recurrent neoplasia after endoscopic papillectomy.Endoscopy international open · 2025Review
- The Prognostic Significance of the CALLY Index in Ampullary Carcinoma: An Inflammation-Nutrition Retrospective Analysis.Journal of inflammation research · 2025Article
- Long-term Outcomes of Ampullary Adenoma According to Resected Margin Status after Endoscopic Papillectomy.Gut and liver · 2024Article
- Updates on the Management of Ampullary Neoplastic Lesions.Diagnostics (Basel, Switzerland) · 2023Review
- Surgical ampullectomy: A comprehensive review.World journal of gastrointestinal surgery · 2021Review
- Endoscopic papillectomy for ampullary adenomatous lesions: A literature review.World journal of gastrointestinal oncology · 2021Review
- Ampullary Adenocarcinoma: a Mini-Review and a Case Report of a Clinically Stable Disease Patient Treated with Herbal Supplements.Journal of gastrointestinal cancer · 2021Article
- Article
- Trans-duodenal ampullectomy for ampullary neoplasms: early and long-term outcomes in 36 consecutive patients.Surgical endoscopy · 2020Article
- Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer.PloS one · 2020Article
- Very early recurrence following pancreaticoduodenectomy in patients with ampullary cancer.Medicine · 2019Article
- Transduodenal ampullectomy for ampullary tumors - single center experience of consecutive 26 patients.Annals of surgical treatment and research · 2018Article
- Racial and ethnic disparities in a national cohort of ampullary cancer patients.Journal of surgical oncology · 2018Article
- Case series of papillectomy by endoscopic retrograde cholangiopancreatography (ERCP).Medical journal of the Islamic Republic of Iran · 2018Article
- Clinicopathologic and survival analysis of resected ampullary adenocarcinoma.Journal of surgical oncology · 2016Article
- Transduodenal ampullectomy provides a less invasive technique to cure early ampullary cancer.BMC surgery · 2016Article
- Transduodenal Ampullectomy for the Treatment of Early-Stage Ampulla of Vater Cancer.World journal of surgery · 2016Article
- Distal bile duct carcinomas and pancreatic ductal adenocarcinomas: postulating a common tumor entity.Cancer medicine · 2016Review
- Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with PT1-3N0M0 esophageal squamous cell carcinoma.OncoTargets and therapy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly ampullary cancers present with good prognosis. Pancreaticoduodenectomy (PD) has been standard treatment for ampullary cancers, but it remains high rate of postoperative complications. So there raises a discussion on the role of local ampullectomy for early ampullary cancers (mainly focusing on pT1).
methods89 patients with pT1 ampullary cancer who underwent surgical treatment between 1978 and 2010 were retrospectively studied.
resultsRate of postoperative complications, especially post-operative pancreatic fistula (P = 0.009), after PD was higher than after local ampullectomy, . Multivariate analysis showed that tumor size (HR 2.204; P = 0.014), lymph node metastasis (HR 4.362; P < 0.001), lymph vascular invasion (HR 4.258; P < 0.001), and perineural invasion (HR 4.467; P < 0.001), gross morphology (HR 2.536; P = 0.004) and tumor grade (HR 4.213; P = 0.001) were independent risk factors for long-term survival, as well as risk factors for failure of ampullectomy in early ampullary cancer. For patients absent of these factors, local ampullectomy would achieve a good prognosis.
conclusionsBecause of high rate of lymph node metastasis, PD should be preferably performed for radical resection. Local ampullectomy could be an alternative for patients in high operative risk; and would achieve a good outcome in patients whose tumors were well differentiated and showed polypoid gross morphology and size ≤1 cm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.