Evidence map›Paper›PMID 25887992›Full record

ReviewAdvanced drug delivery reviews2015

MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells.

Sang-Ging Ong, Won Hee Lee, Kazuki Kodo, Joseph C Wu

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. HIF1α controls steroidogenesis under acute hypoxic stress.Cell communication and signaling : CCS · 2025
    Article
  6. Live-Cell Imaging of miRNAs with the Combination of CHA and HCR Techniques.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. A Novel miRNA From Egg-Derived Exosomes ofFrontiers in immunology · 2022
    Article
  16. Review
  17. A Review of miR-326 and Female Related Diseases.Acta histochemica et cytochemica · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sang-Ging OngStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA, United States.
Won Hee LeeStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA, United States.
Kazuki KodoStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA, United States.
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States; Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA, United States; Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States; Institute of Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: joewu@stanford.edu.

Funding

Project 3: Effect of Age and Longevity Genes on Epigenomic MechanismsP01GM099130 · NIGMS · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2011 to 2015
$11.4M
iPSC Derived EC as Surrogates Using Pulmonary Hypertension as a Prototype DiseaseU01HL107393 · NHLBI · STANFORD UNIVERSITY · PI RABINOVITCH, MARLENE, SNYDER, MICHAEL P. · 2011 to 2015
$8.7M
Molecular Imaging of Targeted Cardiac Gene TherapyR01HL093172 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2009 to 2015
$2.7M
Molecular Imaging of Cardiac Stem Cell TherapyR01EB009689 · NIBIB · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2010 to 2013
$1.4M
NHLBI NIH HHS R01 HL093172NHLBI NIH HHS U01 HL107393NIBIB NIH HHS R01 EB009689NIGMS NIH HHS P01 GM099130
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are key components of a broadly conserved post-transcriptional mechanism that controls gene expression by targeting mRNAs. miRNAs regulate diverse biological processes, including the growth and differentiation of stem cells as well as the regulation of both endogenous tissue repair that has critical implications in the development of regenerative medicine approaches. In this review, we first describe key features of miRNA biogenesis and their role in regulating self-renewal, and then discuss the involvement of miRNAs in the determination of cell fate decisions. We highlight the role of miRNAs in the emergent field of reprogramming and trans-differentiation of somatic cells that could further our understanding of miRNA biology and regenerative medicine applications. Finally, we describe potential techniques for proper delivery of miRNAs in target cells.

Indexed as

Gene Transfer TechniquesAnimalsCell DifferentiationCell Self RenewalCell TransdifferentiationCellular ReprogrammingEmbryonic Stem CellsHumansMicroRNAsOrganelle BiogenesisRegenerative MedicineMicroRNAsDifferentiationmicroRNAsRegenerative medicineReprogrammingSelf-renewalTrans-differentiation

Identifiers

PMID25887992
PMCPMC4546706

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.