ArticleBMC genomics2015
Analysis of whole genome sequencing for the Escherichia coli O157:H7 typing phages.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
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- A VersaTile Approach to Reprogram the Specificity of the R2-Type Tailocin Towards Different Serotypes ofAntibiotics (Basel, Switzerland) · 2025Article
- Molecular characterization and safety properties of multi drug-resistant Escherichia coli O157:H7 bacteriophages.BMC microbiology · 2024Article
- Analysis ofMicrobial genomics · 2023Article
- Advances in bacteriophage-mediated strategies for combating polymicrobial biofilms.Frontiers in microbiology · 2023Review
- Investigation of Phages InfectingPHAGE (New Rochelle, N.Y.) · 2021Article
- Development of Styrene Maleic Acid Lipid Particles as a Tool for Studies of Phage-Host Interactions.Journal of virology · 2020Article
- Article
- Genetic Diversity of Non-O157 Shiga Toxin-ProducingFrontiers in microbiology · 2020Article
- Still Something to Discover: Novel Insights intoViruses · 2019Article
- Phage Predation Shapes the Population Structure of Shiga-ToxigenicFrontiers in genetics · 2019Article
- Article
- Characterization of two polyvalent phages infecting Enterobacteriaceae.Scientific reports · 2017Article
- Evolution of a zoonotic pathogen: investigating prophage diversity in enterohaemorrhagicMicrobial genomics · 2016Article
- Short-term evolution of Shiga toxin-producingMicrobial genomics · 2016Article
- Development of an Assay for the Identification of Receptor Binding Proteins from Bacteriophages.Viruses · 2016Article
- Assessing Illumina technology for the high-throughput sequencing of bacteriophage genomes.PeerJ · 2016Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundShiga toxin producing Escherichia coli O157 can cause severe bloody diarrhea and haemolytic uraemic syndrome. Phage typing of E. coli O157 facilitates public health surveillance and outbreak investigations, certain phage types are more likely to occupy specific niches and are associated with specific age groups and disease severity. The aim of this study was to analyse the genome sequences of 16 (fourteen T4 and two T7) E. coli O157 typing phages and to determine the genes responsible for the subtle differences in phage type profiles.
resultsThe typing phages were sequenced using paired-end Illumina sequencing at The Genome Analysis Centre and the Animal Health and Veterinary Laboratories Agency and bioinformatics programs including Velvet, Brig and Easyfig were used to analyse them. A two-way Euclidian cluster analysis highlighted the associations between groups of phage types and typing phages. The analysis showed that the T7 typing phages (9 and 10) differed by only three genes and that the T4 typing phages formed three distinct groups of similar genomic sequences: Group 1 (1, 8, 11, 12 and 15, 16), Group 2 (3, 6, 7 and 13) and Group 3 (2, 4, 5 and 14). The E. coli O157 phage typing scheme exhibited a significantly modular network linked to the genetic similarity of each group showing that these groups are specialised to infect a subset of phage types.
conclusionSequencing the typing phage has enabled us to identify the variable genes within each group and to determine how this corresponds to changes in phage type.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.