ArticleGenetics, selection, evolution : GSE2015
A missense mutation in the agouti signaling protein gene (ASIP) is associated with the no light points coat phenotype in donkeys.
Article in Genetics, selection, evolution : GSE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 23 citations in OpenAlex.
- Coat colour in marsupials: genetic variants at theRoyal Society open science · 2024Article
- Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes.Animals : an open access journal from MDPI · 2024Review
- Whole-genome sequencing reveals the artificial selection and local environmental adaptability of pigeons (Evolutionary applications · 2022Article
- Detection of Selection Signatures Underlying Production and Adaptive Traits Based on Whole-Genome Sequencing of Six Donkey Populations.Animals : an open access journal from MDPI · 2020Article
- Genomic Characteristics and Selection Signatures in Indigenous Chongming White Goat (Frontiers in genetics · 2020Article
- Comparative transcriptome analysis reveals the genetic basis of coat color variation in Pashmina goat.Scientific reports · 2019Article
- Chromosomal Localization of Candidate Genes for Fiber Growth and Color in Alpaca (Frontiers in genetics · 2019Article
- Comparative FISH-Mapping ofFrontiers in genetics · 2019Article
- Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene.Asian-Australasian journal of animal sciences · 2017Article
- Genome Wide Association Study Identifies New Loci Associated with Undesired Coat Color Phenotypes in Saanen Goats.PloS one · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSeven donkey breeds are recognized by the French studbook and are characterized by a black, bay or grey coat colour including light cream-to-white points (LP). Occasionally, Normand bay donkeys give birth to dark foals that lack LP and display the no light points (NLP) pattern. This pattern is more frequent and officially recognized in American miniature donkeys. The LP (or pangare) phenotype resembles that of the light bellied agouti pattern in mouse, while the NLP pattern resembles that of the mammalian recessive black phenotype; both phenotypes are associated with the agouti signaling protein gene (ASIP).
findingsWe used a panel of 127 donkeys to identify a recessive missense c.349 T > C variant in ASIP that was shown to be in complete association with the NLP phenotype. This variant results in a cysteine to arginine substitution at position 117 in the ASIP protein. This cysteine is highly-conserved among vertebrate ASIP proteins and was previously shown by mutagenesis experiments to lie within a functional site. Altogether, our results strongly support that the identified mutation is causative of the NLP phenotype.
conclusionsThus, we propose to name the c.[349 T > C] allele in donkeys, the a(nlp) allele, which enlarges the panel of coat colour alleles in donkeys and ASIP recessive loss-of-function alleles in animals.
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