ReviewCurrent opinion in nephrology and hypertension2015
Counting glomeruli and podocytes: rationale and methodologies.
Review in Current opinion in nephrology and hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Epigallocatechin-3-gallate attenuates oxidative stress and apoptosis in podocytes of focal segmental glomerulosclerosis.Renal failure · 2026Article
- Glomage: A Multimodal Platform for High-Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025Review
- Continuous increase in podocyte numbers in the first 36 months of life-insights from forensic autopsies in Japanese children.Pediatric nephrology (Berlin, Germany) · 2025Article
- Fluorescent Water-Soluble Polycationic Chitosan Polymers as Markers for Biological 3D Imaging.Chemical & biomedical imaging · 2024Article
- Preterm Birth and Kidney Health: From the Womb to the Rest of Life.Children (Basel, Switzerland) · 2024Review
- Quantifying Podocyte Number in a Small Sample Size of Glomeruli with CUBIC to Evaluate Podocyte Depletion of db/db Mice.Journal of diabetes research · 2023Article
- PodoCount: A Robust, Fully Automated, Whole-Slide Podocyte Quantification Tool.Kidney international reports · 2022Article
- PodoSighter: A Cloud-Based Tool for Label-Free Podocyte Detection in Kidney Whole-Slide Images.Journal of the American Society of Nephrology : JASN · 2021Article
- Instance segmentation for whole slide imaging: end-to-end or detect-then-segment.Journal of medical imaging (Bellingham, Wash.) · 2021Article
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- MicroRNAs in Podocyte Injury in Diabetic Nephropathy.Frontiers in genetics · 2020Review
- Early Detection of Active Glomerular Lesions in Dogs and Cats Using Podocin.Journal of veterinary research · 2019Article
- The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.Nature communications · 2019Article
- Segmentation of Glomeruli Within Trichrome Images Using Deep Learning.Kidney international reports · 2019Article
- Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants.EBioMedicine · 2018Article
- Graft Growth and Podocyte Dedifferentiation in Donor-Recipient Size Mismatch Kidney Transplants.Transplantation direct · 2017Article
- Deletion of inositol-requiring enzyme-1α in podocytes disrupts glomerular capillary integrity and autophagy.Molecular biology of the cell · 2017Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThere is currently much interest in the numbers of both glomeruli and podocytes. This interest stems from a greater understanding of the effects of suboptimal fetal events on nephron endowment, the associations between low nephron number and chronic cardiovascular and kidney disease in adults, and the emergence of the podocyte depletion hypothesis. RECENT
findingsObtaining accurate and precise estimates of glomerular and podocyte number has proven surprisingly difficult. When whole kidneys or large tissue samples are available, design-based stereological methods are considered gold standard because they are based on principles that negate systematic bias. However, these methods are often tedious and time consuming, and oftentimes inapplicable when dealing with small samples such as biopsies. Therefore, novel methods suitable for small tissue samples, and innovative approaches to facilitate high throughput measurements, such as MRI to estimate glomerular number and flow cytometry to estimate podocyte number, have recently been described. SUMMARY: This review describes current gold-standard methods for estimating glomerular and podocyte number, as well as methods developed in the past 3 years. We are now better placed than ever before to accurately and precisely estimate glomerular and podocyte number, and examine relationships between these measurements and kidney health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.