ArticleGenetics, selection, evolution : GSE2015
Epigenetic regulation of the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.
Article in Genetics, selection, evolution : GSE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Sperm subpopulations differing in mitochondrial abundance show divergent nuclear allele frequencies.PloS one · 2026Article
- Transcription factors and candidate functional SNPs associated with variation in fatty acid composition from skeletal muscle of pigs.Animal genetics · 2025Article
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- Article
- Article
- Integrated Analysis of Long Non-Coding RNA and mRNA to Reveal Putative Candidate Genes Associated with Backfat Quality in Beijing Black Pig.Foods (Basel, Switzerland) · 2022Article
- Association Analysis between Genetic Variants ofBiology · 2022Article
- Genome-wide characterization of lncRNAs and mRNAs in muscles with differential intramuscular fat contents.Frontiers in veterinary science · 2022Article
- Transcriptomic Profiling of Skeletal Muscle Reveals Candidate Genes Influencing Muscle Growth and Associated Lipid Composition in Portuguese Local Pig Breeds.Animals : an open access journal from MDPI · 2021Article
- Double-lobectomy in a steatotic liver transplantation rat model.Experimental and therapeutic medicine · 2021Article
- Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig.Scientific reports · 2020Article
- Estrogen Abolishes the Repression Role of gga-miR-221-5p TargetingInternational journal of molecular sciences · 2020Article
- Sp1 is Involved in Vertebrate LC-PUFA Biosynthesis by Upregulating the Expression of Liver Desaturase and Elongase Genes.International journal of molecular sciences · 2019Article
- Genomic, Transcriptomic, and Epigenomic Features Differentiate Genes That Are Relevant for Muscular Polyunsaturated Fatty Acids in the Common Carp.Frontiers in genetics · 2019Article
- Expression analysis of candidate genes for fatty acid composition in adipose tissue and identification of regulatory regions.Scientific reports · 2018Article
- Modulatory Effects of Breed, Feeding Status, and Diet on Adipogenic, Lipogenic, and Lipolytic Gene Expression in Growing Iberian and Duroc Pigs.International journal of molecular sciences · 2017Article
- Genome-wide association study confirm major QTL for backfat fatty acid composition on SSC14 in Duroc pigs.BMC genomics · 2017Article
- Deciphering the regulation of porcine genes influencing growth, fatness and yield-related traits through genetical genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs.International journal of molecular sciences · 2016Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn previous studies on an Iberian x Landrace cross, we have provided evidence that supported the porcine ELOVL6 gene as the major causative gene of the QTL on pig chromosome 8 for palmitic and palmitoleic acid contents in muscle and backfat. The single nucleotide polymorphism (SNP) ELOVL6:c.-533C > T located in the promoter region of ELOVL6 was found to be highly associated with ELOVL6 expression and, accordingly, with the percentages of palmitic and palmitoleic acids in longissimus dorsi and adipose tissue. The main goal of the current work was to further study the role of ELOVL6 on these traits by analyzing the regulation of the expression of ELOVL6 and the implication of ELOVL6 polymorphisms on meat quality traits in pigs.
resultsHigh-throughput sequencing of BAC clones that contain the porcine ELOVL6 gene coupled to RNAseq data re-analysis showed that two isoforms of this gene are expressed in liver and adipose tissue and that they differ in number of exons and 3'UTR length. Although several SNPs in the 3'UTR of ELOVL6 were associated with palmitic and palmitoleic acid contents, this association was lower than that previously observed with SNP ELOVL6:c.-533C > T. This SNP is in full linkage disequilibrium with SNP ELOVL6:c.-394G > A that was identified in the binding site for estrogen receptor alpha (ERα). Interestingly, the ELOVL6:c.-394G allele is associated with an increase in methylation levels of the ELOVL6 promoter and with a decrease of ELOVL6 expression. Therefore, ERα is clearly a good candidate to explain the regulation of ELOVL6 expression through dynamic epigenetic changes in the binding site of known regulators of ELOVL6 gene, such as SREBF1 and SP1.
conclusionsOur results strongly suggest the ELOVL6:c.-394G > A polymorphism as the causal mutation for the QTL on pig chromosome 8 that affects fatty acid composition in pigs.
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