ArticleBMC pulmonary medicine2015
Sudden death in young persons with uncontrolled asthma--a nationwide cohort study in Denmark.
Article in BMC pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Dysregulated tissue immunity in human fatal asthma.Nature communications · 2026Article
- A cost-effectiveness analysis comparing single-inhaler extrafine beclomethasone/formoterol/glycopyrronium bromide against other SITTs in adult patients with uncontrolled asthma in England.Health economics review · 2025Article
- Autopsy of all young sudden death cases is important to increase survival in family members left behind.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Article
- Recent increase in asthma mortality in Brazil: a warning sign for the public health system.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Observational
- Understanding the Link Between Adult Asthma and Coronary Artery Disease: A Narrative Review.Cureus · 2023Review
- Mild allergic airways responses to an environmental mixture increase cardiovascular risk in rats.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Minocycline prevents hypoxia-induced seizures.Frontiers in neural circuits · 2023Article
- Is Seizure an Adverse Effect of Salbutamol in the Pediatric Population?Balkan medical journal · 2022Article
- Asthma mortality among children and adolescents in China, 2008-2018.World journal of pediatrics : WJP · 2022Article
- A review of the causes and risk factors for sudden unexpected death in the young.Forensic science, medicine, and pathology · 2022Review
- Young adult preferences for digital health interventions to support adherence to inhaled corticosteroids in asthma: a qualitative study.Health psychology and behavioral medicine · 2022Article
- A Smartphone App to Support Adherence to Inhaled Corticosteroids in Young Adults With Asthma: Multi-Methods Feasibility Study.JMIR formative research · 2021Article
- Sudden Death in Adults: A Practical Flow Chart for Pathologist Guidance.Healthcare (Basel, Switzerland) · 2021Review
- The Myth of Mild: Severe Exacerbations in Mild Asthma: An Underappreciated, but Preventable Problem.Advances in therapy · 2021Article
- Asthma Mortality and Hospitalizations in Mexico from 2010 to 2018: Retrospective Epidemiologic Profile.International journal of environmental research and public health · 2020Article
- Use of population data for assessing trends in work-related asthma mortality.Current opinion in allergy and clinical immunology · 2019Review
- Uncovering the mechanism of Maxing Ganshi Decoction on asthma from a systematic perspective: A network pharmacology study.Scientific reports · 2018Article
- Article
- Unexpected death in palliative care: what to expect when you are not expecting.Current opinion in supportive and palliative care · 2015Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a common chronic disease among young adults, and several studies have reported increased mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwide setting in patients with uncontrolled asthma. We defined uncontrolled asthma as a previous hospital admittance because of asthma (of any severity) or when asthma was considered to have influenced the death according to the death certificate. The purpose of this study is to increase the medical focus on young persons with uncontrolled asthma and thereby hopefully aid in preventing sudden unexpected deaths. We therefore aimed to describe clinical characteristics, symptoms, causes of death, and contact with the healthcare system prior to sudden unexpected death in young persons with uncontrolled asthma.
methodsThrough the review of death certificates, we found 625 sudden unexpected death cases in individuals aged 1-35 years in Denmark from 2000 to 2006. Of those, 49 persons with uncontrolled asthma were identified. Previous contacts with the healthcare system were identified, and available records from general practitioners were retrieved.
resultsWe identified 49 individuals who suffered from uncontrolled asthma. This corresponds to an incidence rate of 0.32 per 100,000 person-years. The cause of death in 31 cases (63%) was sudden cardiac death, and in 13 cases (27%), it was a fatal asthma attack. Symptoms (chest pain, dyspnea, seizures, general malaise, syncope, and palpitations) prior to death were reported in 41 (84%) of the cases. In 34 (69%) of the cases, antecedent symptoms (symptoms >24 hours before death) were present, and 28 (57%) patients had prodromal symptoms (symptoms <24 hours before death). The most common antecedent symptoms were dyspnea and chest pain, whereas the most common prodromal symptoms were dyspnea, general malaise, and/or fatigue. Twenty-eight patients (57%) sought medical advice from a general practitioner and/or emergency department due to these symptoms.
conclusionThe cause of death was predominantly sudden cardiac death followed by fatal asthma attack. We found that 41 (84%) of patients suffered from symptoms prior to death and that 28 (57%) sought medical advice from the emergency department and/or general practitioners.
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