ArticleBMC endocrine disorders2015
Association between lipids profile and thyroid parameters in euthyroid diabetic subjects: a cross-sectional study.
Article in BMC endocrine disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 38 citations in OpenAlex.
- A Retrospective Analysis of the Changes in Prediabetes-Associated Markers of Thyroid Function in Patients from Durban, South Africa.International journal of molecular sciences · 2025Article
- Lipoprotein Ratios: Correlation With Glycated Hemoglobin (HbA1c) Among Thyroid Disorders' Patients.Cureus · 2024Article
- The Impact of Laparoscopic Sleeve Gastrectomy on Thyroid Functions in Egyptian Patients with Obesity.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Hypothyroidism correlates with dyslipidemia and protein contents in patients with various metabolic disorders.The Journal of international medical research · 2022Article
- Thyroid Function Before and After Laparoscopic Sleeve Gastrectomy in Patients with Obesity.Obesity surgery · 2022Article
- Association of thyroid hormone with body fat content and lipid metabolism in euthyroid male patients with type 2 diabetes mellitus: a cross-sectional study.BMC endocrine disorders · 2021Article
- The thyroid hormone levels and glucose and lipid metabolism in children with type 1 diabetes: a correlation analysis.Translational pediatrics · 2021Article
- Article
- L-thyroxine malabsorption due to calcium carbonate impairs blood pressure, total cholesterolemia, and fasting glycemia.Endocrine · 2019Article
- Association between Thyroid Hormone Levels and Diabetic Kidney Disease in Euthyroid Patients with Type 2 Diabetes.Scientific reports · 2018Article
- BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults.International journal of endocrinology · 2017Article
- CORRELATION BETWEEN SUBCLINICAL HYPOTHYROIDISM AND DYSLIPIDEMIA IN WOMEN IN NORTHEAST CHINA.Acta endocrinologica (Bucharest, Romania : 2005)Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe concept is now emerging that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The aim of this study was to investigate the potential association between thyroid parameters and lipids profile in a cohort of euthyroid diabetic subjects.
methodsFour hundred and sixty-two euthyroid type 2 diabetes subjects (302 males and 160 females) were consecutively recruited. Clinical and anthropometric data was collected from all participants. Whole blood samples were drawn in the morning after an overnight fasting for the measurement of serum TSH, free thyroxine (FT4), free triiothyronine (FT3), anti-thyroid peroxidase antibody (TPO-Ab) levels, as well as lipid concentrations and glucose.
resultsTSH was higher in females than males. Stratified by TSH, high-density lipoprotein cholesterol (HDL-c) level increased in subjects with TSH ≥2.5uIU/mL (P = 0.004). And TSH was associated with HDL-c in a Pearson correlation test, however, the association failed to attain significance in partial correlation analyses, adjusted for age, sex, duration of diabetes, fasting glucose and BMI. In females, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) level was significant lower in subjects with TSH <2.5uIU/mL. TSH was significantly associated with TC and LDL-c, even in a partial correlation analysis (P = 0.006 and 0.011, respectively). In a multiple linear regression analysis (stepwise), TSH was positive associated with TC (β = 0.202, P = 0.005) and LDL-c (β = 0.144, P = 0.010). In one hundred and six patients having TPO antibody assays, 6 (5.66%) were positive. The blood pressure and lipid levels were lower in TPO-Ab positive patients, however, the differences were not significantly.
conclusionsIn conclusion, we identified TSH was positively associated with serum TC and LDL-c in euthyroid diabetic women. Our analysis in the subgroup having TPO antibody assays demonstrating non-significantly lower TC levels among seropositive subjects was consistent with the above stated consideration for women as a whole. Further investigations are needed to understand the intimate mechanisms of lipid metabolism in type 2 diabetes with respect to thyroid function.
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