Evidence map›Paper›PMID 25887613›Full record

ReviewCurrent opinion in infectious diseases2015

Host factors that contribute to recurrent staphylococcal skin infection.

Christopher P Montgomery, Michael Z David, Robert S Daum

Abstract readReview
In one paragraph

Review in Current opinion in infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Article
  3. Frontiers in immunology · 2025
    Article
  4. iScience · 2024
    Article
  5. Ultrasound-Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review.Chembiochem : a European journal of chemical biology · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Synergistic Microbicidal Effect of AUR and PEITC AgainstFrontiers in cellular and infection microbiology · 2022
    Article
  13. Observational
  14. Staphylococcus aureus Skin and Soft Tissue Infection Recurrence Rates in Outpatients: A Retrospective Database Study at 3 US Medical Centers.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher P MontgomeryaSections of Critical Care bInfectious Diseases, Department of Pediatrics cSection of Infectious Diseases and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Michael Z David
Robert S Daum

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Spread of Community-Acquired MRSA Among Household ContactsR01AI067584 · NIAID · UNIVERSITY OF CHICAGO · PI DAUM, ROBERT S. · 2007 to 2010
$2.4M
A New Approach to Staphylococcus aureus Vaccine Development - Resubmission 01R01AI103342 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DAUM, ROBERT S., LEE, JEAN CLAIRE · 2013 to 2016
$2.1M
Recurrent MRSA Infections: A Study of Risk Factors and Molecular EpidemiologyK23AI095361 · NIAID · UNIVERSITY OF CHICAGO · PI DAVID, MICHAEL ZDENEK · 2011 to 2015
$633k
Pathophysiology of Staphylococcus aureaus Necrotizing Pneumonia and Severe SepsisK08AI076596 · NIAID · UNIVERSITY OF CHICAGO · PI MONTGOMERY, CHRISTOPHER · 2009 to 2013
$629k
NCATS NIH HHS UL1 TR000430NIAID NIH HHS AI067584NIAID NIH HHS AI076596NIAID NIH HHS AI095361NIAID NIH HHS AI103342NIAID NIH HHS K08 AI076596NIAID NIH HHS K23 AI095361NIAID NIH HHS R01 AI067584NIAID NIH HHS R01 AI103342
6 · The paper itself

Abstract

purpose of reviewStaphylococcus aureus is the most common cause of skin and soft tissue infections (SSTI) in the United States and elsewhere. Recurrent infections occur frequently in patients with S. aureus SSTI, underscoring the need to better understand the nature of protective immunity against these infections. Here, we review recent findings concerning the host factors that predispose to S. aureus SSTI. RECENT

findingsRecurrent infections occur in nearly half of all patients with S. aureus SSTI. Epidemiologic and environmental factors, such as exposure to healthcare, age, and household contacts with S. aureus SSTI, and contaminated household fomites are associated with recurrence. The majority of the population has evidence of antistaphylococcal antibodies, but whether these are protective remains enigmatic. In contrast, recent clinical and experimental findings clearly highlight the critical roles of innate and T cell-mediated immunity in defense against these infections. S. aureus interferes with innate and adaptive immunity by a number of recently elucidated mechanisms. SUMMARY: Recurrent S. aureus SSTIs are common, suggesting incomplete or absent protective immunity among these patients. Our understanding of protective immunity against recurrent infections is incomplete, and further basic and translational investigation is urgently needed to design strategies to prevent and treat these infections.

Indexed as

Immunity, CellularImmunity, InnateAdaptive ImmunityAnti-Bacterial AgentsAntibodies, BacterialHost-Pathogen InteractionsHumansHygieneRisk FactorsSecondary PreventionStaphylococcal Skin InfectionsStaphylococcus aureusAnti-Bacterial AgentsAntibodies, Bacterial

Identifiers

PMID25887613
PMCPMC4414914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.