SynthesisCritical care (London, England)2015
Validity of administrative data in recording sepsis: a systematic review.
Synthesis in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.Intensive care medicine · 2021Pooled it
- Validity of International Classification of Diseases Codes for Identifying Neuro-Ophthalmic Disease in Large Data Sets: A Systematic Review.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2020Pooled it
- Community-onset sepsis and its public health burden: a systematic review.Systematic reviews · 2016Pooled it
- The German Quality Network Sepsis: study protocol for the evaluation of a quality collaborative on decreasing sepsis-related mortality in a quasi-experimental difference-in-differences design.Implementation science : IS · 2018Trial
- Weekend Hospital Admission and Outcomes Following Emergency Cholecystectomy: A National Analysis of 194,787 Admissions, 2018-2022.Healthcare (Basel, Switzerland) · 2026Article
- Differences in admission to trauma centres by sex among adults with traumatic brain injury: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- The economic value of preventing projected sepsis-related deaths among adults in 79 countries, 2000-2023, with projections to 2050: a modelling study.Critical care (London, England) · 2026Article
- Trends in sepsis-related mortality due to dermatologic infections in the United States: Demographic and geographic patterns from 1999 to 2023.Journal of public health research · 2026Article
- Article
- Novel method for trend change detection and hypothesis generation in hemovigilance: A transfusion-related immunomodulation and blood production changes study.Transfusion · 2026Article
- Think sepsis, write sepsis, code sepsis - patient characteristics associated with sepsis (under-)coding in administrative health data.Infection · 2026Article
- Hospital-Wide Sepsis Detection: A Machine Learning Model Based on Prospectively Expert-Validated Cohort.Journal of clinical medicine · 2026Article
- Rising rates of sepsis in England: an ecological study.Infection · 2025Article
- Patient age at diagnosis and biological sex in association with postoperative outcomes of thyroidectomy for low-risk papillary thyroid cancer in the U.S. Military Health System.Gland surgery · 2025Article
- Short-term surgical outcomes in patients with early- versus average-onset colon adenocarcinoma in the Military Health System.JNCI cancer spectrum · 2025Article
- Impact of community-acquired invasive Escherichia coli disease on mortality and readmissions in elderly patients: a multi-center study in Germany.BMC infectious diseases · 2025Article
- Short-Term Outcomes of Breast Cancer Surgery by Race-Ethnicity in the Military Health System.Annals of surgical oncology · 2025Article
- Peripheral arterial disease prevalence among sepsis hospitalizations and associated outcomes.Journal of vascular surgery · 2025Article
- Blood culture positive sepsis in England, 2017-2018: epidemiological assessment of the commissioning for quality and innovation (CQUIN) sepsis indicator.BMC infectious diseases · 2025Article
- Development and validation of an interpretable machine learning model for retrospective identification of suspected infection for sepsis surveillance: a multicentre cohort study.EClinicalMedicine · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdministrative health data have been used to study sepsis in large population-based studies. The validity of these study findings depends largely on the quality of the administrative data source and the validity of the case definition used. We systematically reviewed the literature to assess the validity of case definitions of sepsis used with administrative data.
methodsEmbase and MEDLINE were searched for published articles with International Classification of Diseases (ICD) coded data used to define sepsis. Abstracts and full-text articles were reviewed in duplicate. Data were abstracted from all eligible full-text articles, including ICD-9- and/or ICD-10-based case definitions, sensitivity (Sn), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV).
resultsOf 2,317 individual studies identified, 12 full-text articles met all eligibility criteria. A total of 38 sepsis case definitions were tested, which included over 130 different ICD codes. The most common ICD-9 codes were 038.x, 790.7 and 995.92, and the most common ICD-10 codes were A40.x and A41.x. The PPV was reported in ten studies and ranged from 5.6% to 100%, with a median of 50%. Other tests of diagnostic accuracy were reported only in some studies. Sn ranged from 5.9% to 82.3%; Sp ranged from 78.3% to 100%; and NPV ranged from 62.1% to 99.7%.
conclusionsThe validity of administrative data in recording sepsis varied substantially across individual studies and ICD definitions. Our work may serve as a reference point for consensus towards an improved and harmonized ICD-coded definition of sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.