Evidence map›Paper›PMID 25887465›Full record

ReviewPain2015

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Jennifer S Gewandter, Robert H Dworkin, Dennis C Turk, John T Farrar, Roger B Fillingim, Ian Gilron, John D Markman, Anne Louise Oaklander, Michael J Polydefkis, Srinivasa N Raja and 23 more

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04309929 (Description of the Analgesia Obtained With the Anesthesiological Protocols Currently Used in Breast Surgery), which is not on this map. Cited by 77 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 9 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04309929 completednot on this mapstarted 2016, after this paper: background citation

Description of the Analgesia Obtained With the Anesthesiological Protocols Currently Used in Breast Surgery

TypeobservationalSponsorCareggi HospitalRan2016 to 2018Enrolled200ConditionsBreast CancerArmsAnalgesics
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 9 syntheses or guidelines pooled it, 142 citations in OpenAlex.

  1. Pooled it
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  5. Topical clonidine for neuropathic pain in adults.The Cochrane database of systematic reviews · 2022
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 18 institutions in 6 countries.

Jennifer S GewandterDepartment of Anesthesiology, University of Rochester, Rochester, NY, USA University of Washington, Seattle, WA, USA University of Pennsylvania, Philadelphia, PA, USA University of Florida, Gainesville, FL, USA Queen's University, Kingston, ON, Canada Harvard University, Boston, MS, USA Johns Hopkins University, Baltimore, MD, USA German Diabetes Center at Heinrich Heine University, Düsseldorf, Germany Lora Group, LLC, Royal Oak, MD, USA American Chronic Pain Association, Rocklin, CA, USA Pfizer and Duke University, Raleigh-Duram, NC, USA GlaxoSmithKline, London, United Kingdom Eli Lilly, Indianapolis, IN, USA Virtuous Pharma, Inc, Raleigh-Durham, NC, USA York University, Toronto, ON, Canada Rigshospitalet, Copenhagen University, Denmark Endo Pharmaceuticals, Inc, Malvern, PA, USA Teva Pharmaceuticals, North Wales, PA, USA AcelRx, Redwood City, CA, USA Arlington, VA, USA Johnson and Johnson, Titusville, NJ, USA Grünenthal GMbH, Aachen, Germany Jazz Pharmaceuticals, Palo Alto, CA, USA.
Robert H Dworkin
Dennis C Turk
John T Farrar
Roger B Fillingim
Ian Gilron
John D Markman
Anne Louise Oaklander
Michael J Polydefkis
Srinivasa N Raja
James P Robinson
Clifford J Woolf
Dan Ziegler
Michael A Ashburn
Laurie B Burke
Penney Cowan
Steven Z George
Veeraindar Goli
Ole X Graff
Smriti Iyengar
Gary W Jay
Joel Katz
Henrik Kehlet
Rachel A Kitt
Ernest A Kopecky
Richard Malamut
Michael P McDermott
Pamela Palmer
Bob A Rappaport
Christine Rauschkolb
Ilona Steigerwald
Jeffrey Tobias
Gary A Walco
University of Rochester · USUniversity of Washington · USHarvard University Press · USJohns Hopkins University · USUniversity of Florida · USAcelRx Pharmaceuticals (United States) · USAmerican Chronic Pain AssociationDuke University · USEli Lilly (United States) · USGlaxoSmithKline (Netherlands) · NLGrünenthal Group (Germany) · DEHeinrich Heine University Düsseldorf · DEJazz Pharmaceuticals (United States) · USJohnson & Johnson (United States) · USQueen's University · CATeva Pharmaceuticals (Czechia) · CZUniversity of Copenhagen · DKYork University · CA

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGER01NS038253 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WOOLF, CLIFFORD J · 1999 to 2017
$8.2M
Neural Plasticity and Inflammatory PainR37NS039518 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2011 to 2017
$4.7M
Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) Public-Private PartnershipU01FD005936 · FDA · UNIVERSITY OF ROCHESTER · PI DWORKIN, ROBERT H · 2016 to 2020
$2.5M
FDA HHS U01 FD005936NIA NIH HHS P30 AG028740NINDS NIH HHS R01 NS038253NINDS NIH HHS R37 NS039518
6 · The paper itself

Abstract

Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Specific design considerations included subject identification, timing and duration of treatment, outcomes, timing of assessment, and adjusting for risk factors in the analyses. We provide a detailed examination of 4 models of chronic pain prevention (ie, chronic postsurgical pain, postherpetic neuralgia, chronic low back pain, and painful chemotherapy-induced peripheral neuropathy). The issues discussed can, in many instances, be extrapolated to other chronic pain conditions. These examples were selected because they are representative models of primary and secondary prevention, reflect persistent pain resulting from multiple insults (ie, surgery, viral infection, injury, and toxic or noxious element exposure), and are chronically painful conditions that are treated with a range of interventions. Improvements in the design of chronic pain prevention trials could improve assay sensitivity and thus accelerate the identification of efficacious interventions. Such interventions would have the potential to reduce the prevalence of chronic pain in the population. Additionally, standardization of outcomes in prevention clinical trials will facilitate meta-analyses and systematic reviews and improve detection of preventive strategies emerging from clinical trials.

Indexed as

Biomedical ResearchChronic PainClinical Trials as TopicCongresses as TopicHumansPain ManagementPractice Guidelines as TopicResearch DesignTime Factors

Identifiers

PMID25887465
PMCPMC5769693
OpenAlexW2090994794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.