Evidence map›Paper›PMID 25887380›Full record

ArticleGut2015

U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients.

Dhiraj Tripathi, Adrian J Stanley, Peter C Hayes, David Patch, Charles Millson, Homoyon Mehrzad, Andrew Austin, James W Ferguson, Simon P Olliff, Mark Hudson and 2 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Gut, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 264 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04786743 nacompletednot on this mapstarted 2021, after this paper: background citation

Timing of Endoscopic Intervention in Patients With Cirrhosis With Acute Variceal Upper Gastrointestinal Hemorrhage (TEACH Trial): a Randomized Clinical Trial

TypeinterventionalSponsorJinling Hospital, ChinaRan2021 to 2026Enrolled412ConditionsAcute Upper Gastrointestinal Hemorrhage, Cirrhosis, Varice Bleed, Gastroesophageal VaricesArmsendoscopic intervention
NCT04932200 unknown statusnot on this mapstarted 2021, after this paper: background citation

A Prospective Multicenter Cohort Study on the Timing of Emergency Endoscopy for Esophagogastric Variceal Bleeding in Cirrhosis

TypeobservationalSponsorRenmin Hospital of Wuhan UniversityRan2021 to 2022Enrolled608ConditionsLiver Cirrhosis, Portal Hypertension, Esophageal Varix Bleeding
3 · Its place in the literature

Who cites it

264 citing papers in PubMed, 18 syntheses or guidelines pooled it.

  1. Optimal Timing of Endoscopic Intervention for Acute Variceal Bleeding in Cirrhotic Patients: A Systematic Review and Meta-Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
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  4. Evidence for preventing EVRB in cirrhotic patients: A systematic review.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025
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  7. Guideline
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  19. Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Trial
  20. Trial

204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Dhiraj TripathiLiver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Adrian J StanleyGI Unit, Glasgow Royal Infirmary, Glasgow, UK.
Peter C HayesLiver Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
David PatchThe Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital and University College London, London, UK.
Charles MillsonGastrointestinal and Liver Services, York Teaching Hospitals NHS Foundation Trust, York, UK.
Homoyon MehrzadDepartment of Interventional Radiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Andrew AustinDepartment of Gastroenterology, Derby Hospitals NHS Foundation Trust, Derby, UK.
James W FergusonLiver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Simon P OlliffDepartment of Interventional Radiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Mark HudsonLiver Unit, Freeman Hospital, Newcastle upon Tyne, UK.
John M ChristieDepartment of Gastroenterology, Royal Devon and Exeter Hospital, Devon, UK.
Clinical Services and Standards Committee of the British Society of Gastroenterology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2000 and have undergone extensive revision by 13 members of the Guidelines Development Group (GDG). The GDG comprises elected members of the BSG liver section, representation from British Association for the Study of the Liver (BASL) and Liver QuEST, a nursing representative and a patient representative. The quality of evidence and grading of recommendations was appraised using the AGREE II tool.The nature of variceal haemorrhage in cirrhotic patients with its complex range of complications makes rigid guidelines inappropriate. These guidelines deal specifically with the management of varices in patients with cirrhosis under the following subheadings: (1) primary prophylaxis; (2) acute variceal haemorrhage; (3) secondary prophylaxis of variceal haemorrhage; and (4) gastric varices. They are not designed to deal with (1) the management of the underlying liver disease; (2) the management of variceal haemorrhage in children; or (3) variceal haemorrhage from other aetiological conditions.

Indexed as

AlgorithmsEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansLiver CirrhosisBLEEDINGCIRRHOSISGASTROINTESTINAL HAEMORRHAGEOESOPHAGEAL VARICESPORTAL HYPERTENSION

Identifiers

PMID25887380
PMCPMC4680175

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.