Evidence map›Paper›PMID 25887374›Full record

Observational studyBMC musculoskeletal disorders2015

Hypovitaminosis D in recent onset rheumatoid arthritis is predictive of reduced response to treatment and increased disease activity: a 12 month follow-up study.

Manuela Di Franco, Ilaria Barchetta, Cristina Iannuccelli, Maria Chiara Gerardi, Silvia Frisenda, Fulvia Ceccarelli, Guido Valesini, Maria Gisella Cavallo

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Effect of vitamin DClinics (Sao Paulo, Brazil) · 2024
    Trial
  2. Trial
  3. Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis.Calcified tissue international · 2020
    Review
  11. Article
  12. Review
  13. Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis.The Journal of steroid biochemistry and molecular biology · 2019
    Article
  14. Article
  15. Article
  16. Skeletal complications of rheumatoid arthritis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Manuela Di FrancoRheumatology Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. manuela.difranco@uniroma1.it.
Ilaria BarchettaInternal Medicine Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. ilariabarchetta@hotmail.com.
Cristina IannuccelliRheumatology Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. critrilly@hotmail.com.
Maria Chiara GerardiRheumatology Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. mariachiara.gerardi@gmail.com.
Silvia FrisendaRheumatology Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. silviafrisenda@libero.it.
Fulvia CeccarelliRheumatology Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. fulviaceccarelli@gmail.com.
Guido ValesiniRheumatology Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. guido.valesini@uniroma1.it.
Maria Gisella CavalloInternal Medicine Unit-Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy. gisella.cavallo@uniroma1.it.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D displays immunomodulatory activities and has been proposed as a potential player in the pathogenesis of rheumatoid arthritis (RA). A negative association between serum 25(OH) vitamin D levels and RA activity was demonstrated but longitudinal studies investigating the role of vitamin D levels in predicting RA activity and response to treatment are lacking. Therefore, this study was designed to test the hypothesis of an association between serum 25(OH) vitamin D levels at RA diagnosis and disease activity evaluated by clinimetric, laboratory and ultrasound (US) parameters and to detect the prevalence of remission and response to treatment after 12 months follow-up.

methodsThis is a longitudinal, retrospective study on data obtained from thirty-seven patients with early RA treatment-naïve. Serum inflammatory markers, auto-antibodies and 25(OH) vitamin D levels were obtained at baseline. Hypovitaminosis D was diagnosed for 25(OH) vitamin D levels < 20 ng/ml. Tender joint count (TJCs), swollen joint count (SJCs), Visual Analog Scales (VAS), Disease Activity Score (DAS) 28 score were assessed at baseline and 12 months after diagnosis. Joints synovitis and power-Doppler were evaluated at baseline and 12 months later.

resultsAt baseline mean 25(OH) vitamin D levels were 24.4 ± 11.9 ng/ml; 35% of study subjects had hypovitaminosis D which strongly associated with higher RA activity and lower prevalence of remission and response to treatment (all p-values < 0.001). The percentage of patients not presenting a reduction of the US synovitis score after 12 months from diagnosis was significantly higher among patients with hypovitaminosis D than in those with normal serum 25(OH) vitamin D at baseline.

conclusionsIn patients with early RA and basal hypovitaminosis D after 12 months follow-up reduction of disease activity and percentage of remission and response to treatment were significantly lower than those observed in patients with normal vitamin D levels. These results provide further support to the immunomodulatory action of vitamin D in RA and suggest a role of basal vitamin D status in the prediction of disease evolution. Vitamin D measurement and possibly vitamin D supplementation should be considered an additional option in the management of early RA patients.

Indexed as

Severity of Illness IndexAdultAntirheumatic AgentsArthritis, RheumatoidAutoantibodiesBiomarkersComorbidityFemaleFollow-Up StudiesHumansIncidenceJointsLongitudinal StudiesMaleMiddle AgedPain MeasurementAntirheumatic AgentsAutoantibodiesBiomarkersVitamin D

Identifiers

PMID25887374
PMCPMC4373034
OpenAlexW2060731839

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.