Evidence map›Paper›PMID 25887362›Full record

Trial reportOsteoarthritis and cartilage2015

The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes.

D J Hunter, D P Beavers, F Eckstein, A Guermazi, R F Loeser, B J Nicklas, S L Mihalko, G D Miller, M Lyles, P DeVita and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Pooled it
  4. Trial
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  8. Trial
  9. Review
  10. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  11. Article
  12. Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

D J HunterRheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, NSW Australia. Electronic address: David.Hunter@sydney.edu.au.
D P BeaversDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
F EcksteinInstitute of Anatomy, Paracelsus Medical University, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
A GuermaziDepartment of Radiology, Boston University School of Medicine, Boston, MA, USA.
R F LoeserThurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.
B J NicklasDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA; Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
S L MihalkoDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.
G D MillerDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.
M LylesSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
P DeVitaDepartment of Kinesiology, East Carolina University, Greenville, NC, USA.
C LegaultDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
J J CarrDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
J D WilliamsonSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
S P MessierDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA; Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
USE OF MOTIVATIONAL INTERVIEWING TO MANAGE TYPE I DIABETESM01RR000211 · NCRR · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DAGOGO-JACK, SAMUEL · 1985 to 2006
$9.6M
Intensive Dietary Restriction with Exercise in ArthritisR01AR052528 · NIAMS · WAKE FOREST UNIVERSITY · PI MESSIER, STEPHEN P · 2006 to 2010
$2.9M
NCRR NIH HHS M01 RR000211NCRR NIH HHS M01-RR00211NIAMS NIH HHS R01 AR052528NIAMS NIH HHS R01 AR052528-01NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG21332
6 · The paper itself

Abstract

purposeReport the radiographic and magnetic resonance imaging (MRI) structural outcomes of an 18-month study of diet-induced weight loss, with or without exercise, compared to exercise alone in older, overweight and obese adults with symptomatic knee osteoarthritis (OA).

methodsProspective, single-blind, randomized controlled trial that enrolled 454 overweight and obese (body mass index, BMI = 27-41 kg m(-2)) older (age ≥ 55 yrs) adults with knee pain and radiographic evidence of femorotibial OA. Participants were randomized to one of three 18-month interventions: diet-induced weight loss only (D); diet-induced weight loss plus exercise (D + E); or exercise-only control (E). X-rays (N = 325) and MRIs (N = 105) were acquired at baseline and 18 months follow-up. X-ray and MRI (cartilage thickness and semi-quantitative (SQ)) results were analyzed to compare change between groups at 18-month follow-up using analysis of covariance (ANCOVA) adjusted for baseline values, baseline BMI, and gender.

resultsMean baseline descriptive characteristics of the cohort included: age, 65.6 yrs; BMI 33.6 kg m(-2); 72% female; 81% white. There was no significant difference between groups in joint space width (JSW) loss; D -0.07 (SE 0.22) mm, D + E -0.27 (SE 0.22) mm and E -0.16 (SE 0.24) mm (P = 0.79). There was also no significant difference in MRI cartilage loss between groups; D -0.10(0.05) mm, D + E -0.13(0.04) mm and E -0.05(0.04) mm (P = 0.42).

conclusionDespite the potent effects of weight loss in this study on symptoms as well as mechanistic outcomes (such as joint compressive force and markers of inflammation), there was no statistically significant difference between the three active interventions on the rate of structural progression either on X-ray or MRI over 18-months.

Indexed as

Diet, ReducingAgedBody Mass IndexCombined Modality TherapyDisease ProgressionExercise TherapyFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedObesityOsteoarthritis, KneeRadiographySeverity of Illness IndexMRIOsteoarthritisWeight lossX-ray

Identifiers

PMID25887362
PMCPMC9178604

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.