Evidence map›Paper›PMID 25887335›Full record

ArticleBMC endocrine disorders2015

Does vitamin D play a significant role in type 2 diabetes?

Jayesh J Sheth, Ankna Shah, Frenny J Sheth, Sunil Trivedi, Mamta Lele, Navneet Shah, Premal Thakor, Rama Vaidya

Open access · goldAbstract read
In one paragraph

Article in BMC endocrine disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 7 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 7 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jayesh J ShethDepartment of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. jshethad1@gmail.com.
Ankna ShahDepartment of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. anknashah@yahoo.co.in.
Frenny J ShethDepartment of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. fshethad1@googlemail.com.
Sunil TrivediDepartment of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. drsuniltrivedi@hotmail.com.
Mamta LeleUnit of Endocrine and Metabolic Disorders, Kasturba Health Society, Medical Research Centre, Mumbai, 400056, India. mamtalele@gmail.com.
Navneet ShahDepartment of Diabetes and Endocrinology, Sterling Hospital, Ahmedabad, 380052, India. navneetnshah2000@gmail.com.
Premal ThakorGujarat Diabetic Association, Ahmedabad, 380007, India. pbthakor36@yahoo.co.uk.
Rama VaidyaUnit of Endocrine and Metabolic Disorders, Kasturba Health Society, Medical Research Centre, Mumbai, 400056, India. rama.vaidya@gmail.com.
Centre For Human Genetics · INKasturba Hospital · INSterling Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects.

methodsPresent study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled study subjects were investigated for biochemical parameters like FBS, PPBS, HbA1c, FI, HOMA-IR and 25OHD levels in blood.

resultsVitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c or HOMA-IR in T2DM cases (p = 0.057 & p = 0.257 respectively) and in control subjects (p = 0.675 & p = 0.647 respectively).

conclusionOur findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.

Indexed as

AdultAgedCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedRisk FactorsVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D

Identifiers

PMID25887335
PMCPMC4357062
OpenAlexW2067334274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.