ArticleBMC genomics2015
Modelling the genetic architecture of flowering time control in barley through nested association mapping.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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Who cites it
119 citing papers in PubMed.
- An IRAT109 NAM population: Genetic characterization and mapping utility for trait dissection in japonica rice (Oryza sativa L.).The plant genome · 2026Article
- Haplotype-based nested association mapping for net form net blotch response in Australian barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Quantification of Stress- and Resistance-Related Metabolites in Barley Leaves (Journal of agricultural and food chemistry · 2026Article
- Decoding the Genetic Basis of Salinity Tolerance at Germination and Seedling Traits in HEB-25 Barley NAM Population.Plants (Basel, Switzerland) · 2026Article
- Korean Soybean Nested Association Mapping (K-SoyNAM) population: genetic linkage map, genetic mapping, and genotype imputation.BMC genomics · 2026Article
- Unlocking salt tolerance from Fertile Crescent wild barley: evolutionary and physiological mechanisms in introgressed lines.Scientific reports · 2026Article
- Introgression of wild barley alleles improves seedlings salinity tolerance in the nested association mapping HEB-400 population.The plant genome · 2026Article
- Unveiling the Genomic Architecture of Phenotypic Plasticity Using Multiple GWAS Approaches Under Contrasting Conditions of Water Availability: A Model for Barley.International journal of molecular sciences · 2026Article
- From photoperiod thresholds to photoperiod sensitivity: dual strategies for cost-effective speed breeding and climate-ready barley.Frontiers in plant science · 2026Article
- Tillering plasticity of drought-stressed barley genotypes under different re-watering regimes.BMC plant biology · 2025Article
- UPLC-ESI-TOF-MS Profiling of Metabolome Alterations in Barley (Journal of agricultural and food chemistry · 2025Article
- On the origin of the late-flowering ppd-H1 allele in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Comparative transcriptome analysis reveals candidate gene for flowering time QTL HvHeading in barley.BMC plant biology · 2025Article
- Exploring the multifaceted dynamics of flowering time regulation in field crops: Insight and intervention approaches.The plant genome · 2025Review
- Characterization of a G. max × G. soja nested association mapping population and identification of loci controlling seed composition traits from wild soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Article
- Identification of Quantitative Trait Loci Associated with Plant Adaptation Traits Using Nested Association Mapping Population.Plants (Basel, Switzerland) · 2024Article
- Investigating the genetic control of plant development in spring barley under speed breeding conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genetic mapping reveals new loci and alleles for flowering time and plant height using the double round-robin population of barley.Journal of experimental botany · 2024Article
- Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBarley, globally the fourth most important cereal, provides food and beverages for humans and feed for animal husbandry. Maximizing grain yield under varying climate conditions largely depends on the optimal timing of flowering. Therefore, regulation of flowering time is of extraordinary importance to meet future food and feed demands. We developed the first barley nested association mapping (NAM) population, HEB-25, by crossing 25 wild barleys with one elite barley cultivar, and used it to dissect the genetic architecture of flowering time.
resultsUpon cultivation of 1,420 lines in multi-field trials and applying a genome-wide association study, eight major quantitative trait loci (QTL) were identified as main determinants to control flowering time in barley. These QTL accounted for 64% of the cross-validated proportion of explained genotypic variance (pG). The strongest single QTL effect corresponded to the known photoperiod response gene Ppd-H1. After sequencing the causative part of Ppd-H1, we differentiated twelve haplotypes in HEB-25, whereof the strongest exotic haplotype accelerated flowering time by 11 days compared to the elite barley haplotype. Applying a whole genome prediction model including main effects and epistatic interactions allowed predicting flowering time with an unmatched accuracy of 77% of cross-validated pG.
conclusionsThe elaborated causal models represent a fundamental step to explain flowering time in barley. In addition, our study confirms that the exotic biodiversity present in HEB-25 is a valuable toolbox to dissect the genetic architecture of important agronomic traits and to replenish the elite barley breeding pool with favorable, trait-improving exotic alleles.
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