Evidence map›Paper›PMID 25887311›Full record

ArticleCritical care (London, England)2015

Renal angina: concept and development of pretest probability assessment in acute kidney injury.

Lakhmir S Chawla, Stuart L Goldstein, John A Kellum, Claudio Ronco

Abstract read
In one paragraph

Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Pediatric acute kidney injury: new advances in the last decade.Kidney research and clinical practice · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Clinical significance of urinary L-FABP in the emergency department.International journal of emergency medicine · 2019
    Article
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lakhmir S ChawlaDepartment of Medicine, Division of Intensive Care Medicine and Division of Nephrology, Veterans Affairs Medical Center, 50 Irving Street, Washington, DC, 20422, USA. minkchawla@gmail.com.
Stuart L GoldsteinCenter for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7022, RILF2, Cininnati, OH, USA. stuart.goldstein@cchmc.org.
John A KellumDepartment of Critical Care Medicine, Center for Critical Care Nephrology, The CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA, 15261, USA. kellumja@ccm.upmc.edu.
Claudio RoncoDepartment of Nephrology, Dialysis & Transplantation, International Renal Research Institute, San Bortolo Hospital, Via Bertesina, Vicenza, 36100, Italy. cronco@goldnet.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The context of a diagnostic test is a critical component for the interpretation of its result. This context defines the pretest probability of the diagnosis and forms the basis for the interpretation and value of adding the diagnostic test. In the field of acute kidney injury, a multitude of early diagnostic biomarkers have been developed, but utilization in the appropriate context is less well understood and has not been codified until recently. In order to better operationalize the context and pretest probability assessment for acute kidney injury diagnosis, the renal angina concept was proposed in 2010 for use in both children and adults. Renal angina has been assessed in approximately 1,000 subjects. However, renal angina as a concept is still unfamiliar to most clinicians and the rationale for introducing the term is not obvious. We therefore review the concept and development of renal angina, and the currently available data validating it. We discuss the various arguments for and against this construct. Future research testing the performance of renal angina with acute kidney injury biomarkers is warranted.

Indexed as

Acute Kidney InjuryAdultBiomarkersChildDiagnosis, DifferentialEarly DiagnosisHumansRisk FactorsBiomarkers

Identifiers

PMID25887311
PMCPMC4344798

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.