ArticleBMC microbiology2015
Endemic and epidemic Acinetobacter baumannii clones: a twelve-year study in a tertiary care hospital.
Article in BMC microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Relationship between antibiotic resistance and biofilm-forming capacity with RND efflux pumps expression in clinical Acinetobacter baumannii isolates.Archives of microbiology · 2025Article
- Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.BMC microbiology · 2025Article
- Molecular epidemiology and molecular typing methods ofSaudi medical journal · 2024Review
- A bioinformatic approach to identify confirmed and probable CRISPR-Cas systems in theFrontiers in microbiology · 2024Article
- Genotypic characterization and clonal relatedness of metallo-β-lactamase-producing non-fermentative gram negative bacteria in the first 5 years of their circulation in Paraguay (2011-2015).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- A 12-year epidemiological study ofAntimicrobial stewardship & healthcare epidemiology : ASHE · 2022Article
- Molecular typing and antibiotic resistance patterns among clinical isolates ofFrontiers in microbiology · 2022Article
- Discrimination of hospital isolates of Acinetobacter baumannii using repeated sequences and whole genome alignment differential analysis.Journal of applied genetics · 2021Article
- Extensively drug-resistant Acinetobacter baumannii carrying blaEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Genotyping and molecular characterization of clinicalPathogens and global health · 2020Article
- Molecular characteristics of carbapenem-resistant Acinetobacter spp. from clinical infection samples and fecal survey samples in Southern China.BMC infectious diseases · 2019Article
- Dynamics of a Sporadic NosocomialFrontiers in microbiology · 2019Article
- Whole-Genome Sequences of FiveFrontiers in microbiology · 2019Article
- Seasonal Occurrence and Carbapenem Susceptibility of BovineFrontiers in microbiology · 2019Article
- A multimodal intervention program to control a long-termAntimicrobial resistance and infection control · 2019Article
- Multidrug-Resistant Gram-Negative Bacilli: A Retrospective Study of Trends in a Tertiary Healthcare Unit.Medicina (Kaunas, Lithuania) · 2018Observational
- Distribution of virulence-associated genes and antimicrobial susceptibility in clinicalOncotarget · 2018Article
- Emergence and Persistence of High-Risk Clones Among MDR and XDRFrontiers in microbiology · 2018Article
- Extensively drug-resistantInfection and drug resistance · 2018Article
- An antibiotic stewardship exercise in the ICU: building a treatment algorithm for the management of ventilator-associated pneumonia based on local epidemiology and the 2016 Infectious Diseases Society of America/American Thoracic Society guidelines.Infection and drug resistance · 2018Article
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8 authors.
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Abstract
backgroundNosocomial outbreaks of multidrug-resistant Acinetobacter baumannii are of worldwide concern. Using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and multiple locus variable number tandem repeat sequence (VNTR) analysis (MLVA), the present work examines the genetic diversity of the endemic and epidemic A. baumannii clones isolated in a single hospital over a twelve-year period.
resultsPFGE analysis of 405 A. baumannii-calcoaceticus complex isolates detected 15 A. baumannii endemic/epidemic PFGE types (EE1 to EE15) that grouped into five clusters: EE1-EE8, EE9, EE10, EE11 and EE12-EE15. The MLST sequence type (ST) distributions were: international clone II (ST-2) 60%, international clone III (ST-3) 26.7%, ST-15 6.7%, and ST-80 6.7%. MLVA-8Orsay returned 17 allelic profiles. The large (L) VNTR marker profiles were fully concordant with the detected STs, and concordant with 14 up to 15 PFGE types. Imipenem resistance was detected in five PFGE types; the prevalence of the bla OXA-58-like and bla OXA-40-like genes was 60% and 40% respectively.
conclusionsPFGE proved to be a vital tool for analysis of the temporal and spatial distribution of the clones. MLST and the VNTR L-markers grouped the isolates into clonal clusters. The wide diversity of MLVA small (S)-markers, however, did not permit clustering. The present results demonstrate the persistence of several endemic PFGE types in the hospital, the involvement of some of them in outbreaks, and the inter hospital transmission of extensively drug-resistant ST-15 and ST-80.
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