ArticleBMC evolutionary biology2015
Evidence that natural selection maintains genetic variation for sleep in Drosophila melanogaster.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- The Inversion in(2L)t Impacts Complex, Temperature-Sensitive Behaviors inEcology and evolution · 2026Article
- Strain variation identifies a neural substrate for behavioral evolution in Drosophila.Current biology : CB · 2026Article
- The inversion In(2L)t impacts complex, environmentally sensitive behaviors inbioRxiv : the preprint server for biology · 2025Article
- Adaptive gene expression parallelism in the male reproductive tract of two Drosophila species.Genetics · 2025Article
- Phylogenetic Relatedness Does not Predict Patterns of Parallel Transcriptome Adaptation in Drosophila.Genome biology and evolution · 2025Article
- The Precision and Power of Population Branch Statistics in Identifying the Genomic Signatures of Local Adaptation.Genome biology and evolution · 2025Article
- Aedes albopictus colonies from different geographic origins differ in their sleep and activity levels but not in the time of peak activity.Medical and veterinary entomology · 2024Article
- Intra-species quantification reveals differences in activity and sleep levels in the yellow fever mosquito, Aedes aegypti.Medical and veterinary entomology · 2024Article
- Article
- Genomes from historical Drosophila melanogaster specimens illuminate adaptive and demographic changes across more than 200 years of evolution.PLoS biology · 2023Article
- Selection and geography shape male reproductive tract transcriptomes in Drosophila melanogaster.Genetics · 2023Article
- How Temperature Influences Sleep.International journal of molecular sciences · 2022Review
- Parallel and population-specific gene regulatory evolution in cold-adapted fly populations.Genetics · 2021Article
- Natural selection on sleep duration in Drosophila melanogaster.Scientific reports · 2020Article
- Phenotypic coupling of sleep and starvation resistance evolves in D. melanogaster.BMC evolutionary biology · 2020Article
- Dissecting the Genetic Basis of Variation inGenes · 2020Article
- Patterns of transposable element variation and clinality in Drosophila.Molecular ecology · 2019Article
- Starvation resistance is associated with developmentally specified changes in sleep, feeding and metabolic rate.The Journal of experimental biology · 2019Article
- Parallel clinal variation in the mid-day siesta of Drosophila melanogaster implicates continent-specific targets of natural selection.PLoS genetics · 2018Article
- The origins and evolution of sleep.The Journal of experimental biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDrosophila melanogaster often shows correlations between latitude and phenotypic or genetic variation on different continents, which suggests local adaptation with respect to a heterogeneous environment. Previous phenotypic analyses of latitudinal clines have investigated mainly physiological, morphological, or life-history traits. Here, we studied latitudinal variation in sleep in D. melanogaster populations from North and Central America. In parallel, we used RNA-seq to identify interpopulation gene expression differences.
resultsWe found that in D. melanogaster the average nighttime sleep bout duration exhibits a latitudinal cline such that sleep bouts of equatorial populations are roughly twice as long as those of temperate populations. Interestingly, this pattern of latitudinal variation is not observed for any daytime measure of activity or sleep. We also found evidence for geographic variation for sunrise anticipation. Our RNA-seq experiment carried out on heads from a low and high latitude population identified a large number of gene expression differences, most of which were time dependent. Differentially expressed genes were enriched in circadian regulated genes and enriched in genes potentially under spatially varying selection.
conclusionOur results are consistent with a mechanistic and selective decoupling of nighttime and daytime activity. Furthermore, the present study suggests that natural selection plays a major role in generating transcriptomic variation associated with circadian behaviors. Finally, we identified genomic variants plausibly causally associated with the observed behavioral and transcriptomic variation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.