ArticleSocial cognitive and affective neuroscience2015
FDA cigarette warning labels lower craving and elicit frontoinsular activation in adolescent smokers.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Signs of Warning: Do Health Warning Messages on Sweets Affect the Neural Prefrontal Cortex Activity?Nutrients · 2020Trial
- Effects of Varying Color, Imagery, and Text of Cigarette Package Warning Labels among Socioeconomically Disadvantaged Middle School Youth and Adult Smokers.Health communication · 2019Trial
- Trial
- Adolescents' Responses to Pictorial Warnings on Their Parents' Cigarette Packs.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2016Trial
- Emotional arousal of graphic cigarette warning labels loses its beneficial effects on craving reduction after repeated exposure - A longitudinal neuroimaging study.Drug and alcohol dependence · 2026Article
- Pictorial warning labels reduce sharing intentions, blunt self-relevance processes elicited by social media posts promoting cannabis edibles.The Journal of communication · 2025Article
- Impact of tobacco-pack pictorial warnings on youth and young adults: A systematic review of experimental studies.Tobacco induced diseases · 2019Review
- Brain Responses to Anti-Smoking Health Warnings In Youth.Current addiction reports · 2018Article
- Smokers' Neurological Responses to Novel and Repeated Health Warning Labels (HWLs) From Cigarette Packages.Frontiers in psychiatry · 2018Article
- The persuasion network is modulated by drug-use risk and predicts anti-drug message effectiveness.Social cognitive and affective neuroscience · 2017Article
- Stress and the adolescent brain: Amygdala-prefrontal cortex circuitry and ventral striatum as developmental targets.Neuroscience and biobehavioral reviews · 2016Review
- Young Adult Smokers' Neural Response to Graphic Cigarette Warning Labels.Addictive behaviors reports · 2016Article
- The Age-related Positivity Effect and Tobacco Warning Labels.Tobacco regulatory science · 2016Article
- Functional brain imaging predicts public health campaign success.Social cognitive and affective neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cigarette smoking is an economically and epidemiologically expensive public health concern. Most adult smokers become addicted during adolescence, rendering it a crucial period for prevention and intervention. Although litigation claims have delayed implementation, graphic warning labels proposed by the U.S. Food and Drug Administration (FDA) may be a promising way to achieve this goal. We aimed to determine the efficacy of the labels in reducing in-scanner craving and to characterize the neurobiological responses in adolescent and adult smokers and non-smokers. While undergoing functional magnetic resonance imaging, thirty-nine 13- to 18-year-old adolescent and forty-one 25- to 30-year-old adult smokers and non-smokers rated their desire to smoke when presented with emotionally graphic warning labels and comparison non-graphic labels. Compared with adult smokers, adolescent smokers exhibited greater craving reduction in response to the warning labels. Although smokers evinced overall blunted recruitment of insula and dorsolateral prefrontal cortex (DLPFC) relative to non-smokers, an effect that was stronger in adolescent smokers, parametrically increasing activation of these regions was associated with greater craving reduction. Functional connectivity analyses suggest that greater DLPFC regulation of limbic regions predicted cigarette craving. These data underscore a prominent role of frontoinsular circuitry in predicting the efficacy of FDA graphic warning labels in craving reduction in adult and adolescent smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.