Evidence map›Paper›PMID 25887036›Full record

Trial reportBMC urology2015

Prostatic arterial embolization for the treatment of lower urinary tract symptoms due to large (>80 mL) benign prostatic hyperplasia: results of midterm follow-up from Chinese population.

Mao Qiang Wang, Li Ping Guo, Guo Dong Zhang, Kai Yuan, Kai Li, Feng Duan, Jie Yu Yan, Yan Wang, Hai Yan Kang, Zhi Jun Wang

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMC urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 8 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 8 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mao Qiang WangDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. wangmq@vip.sina.com.
Li Ping GuoDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. guoliping7521@126.com.
Guo Dong ZhangDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. guodongbear@sina.com.
Kai YuanDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. yuankai80601@126.com.
Kai LiDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. 301likai@sina.com.
Feng DuanDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. duanfeng@vip.sina.com.
Jie Yu YanDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. mczlks@sina.com.
Yan WangDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. wang_yan_301@163.com.
Hai Yan KangDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. xhkhy@163.com.
Zhi Jun WangDepartment of Interventional Radiology, Chinese PLA General Hospital Beijing, 100853, Beijing, People's Republic of China. 13811023876@163.com.
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, large prostate size (>80 mL) of benign prostatic hyperplasia (BPH) still pose technical challenges for surgical treatment. This prospective study was designed to explore the safety and efficacy of prostatic arterial embolization (PAE) as an alternative treatment for patients with lower urinary tract symptoms (LUTS) due to largeBPH.

methodsA total of 117 patients with prostates >80 mL were included in the study; all were failure of medical treatment and unsuited for surgery. PAE was performed using combination of 50-μm and 100-μm particles in size, under local anaesthesia by a unilateral femoral approach. Clinical follow-up was performed using the international prostate symptoms score (IPSS), quality of life (QoL), peak urinary flow (Qmax), post-void residual volume (PVR), international index of erectile function short form (IIEF-5), prostatic specific antigen (PSA) and prostatic volume (PV) measured by magnetic resonance (MR) imaging, at 1, 3, 6 and every 6 months thereafter.

resultsThe prostatic artery origins in this study population were different from previously published results. PAE was technically successful in 109 of 117 patients (93.2%). Follow-up data were available for the 105 patients with a mean follow-up of 24 months. The clinical improvements in IPSS, QoL, Qmax, PVR, and PV at 1, 3, 6, 12, and 24 months was 94.3%, 94.3%, 93.3%, 92.6%, and 91.7%, respectively. The mean IPSS (pre-PAE vs post-PAE 26.0 vs 9.0; P < .0.01), the mean QoL (5.0 vs 3.0; P < 0.01), the mean Qmax (8.5 vs 14.5; P < 0.01), the mean PVR (125.0 vs 40.0; P < 0.01), and PV (118.0 vs 69.0, with a mean reduction of 41.5%; P < 0.01 ) at 24-month after PAE were significantly different with respect to baseline. The mean IIEF-5 was not statistically different from baseline. No major complications were noted.

conclusionsPAE is a safe and effective treatment method for patients with LUTS due to large volume BPH. PAE may play an important role in patients in whom medical therapy has failed, who are not candidates for open surgery or TURP or refuse any surgical treatment.

Indexed as

AgedAged, 80 and overChinaEmbolization, TherapeuticErectile DysfunctionHumansLower Urinary Tract SymptomsMaleMiddle AgedPatient SatisfactionProstatic HyperplasiaQuality of LifeRisk AssessmentTreatment Outcome

Identifiers

PMID25887036
PMCPMC4403829
OpenAlexW2086561958

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.