ArticleBMC neuroscience2015
Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats.
Article in BMC neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Astrocytes as Guardians of Neuronal Excitability: Mechanisms Underlying Epileptogenesis.Frontiers in neurology · 2020Review
- Effects of Constitutive and Acute Connexin 36 Deficiency on Brain-Wide Susceptibility to PTZ-Induced Neuronal Hyperactivity.Frontiers in molecular neuroscience · 2020Article
- Review about gabapentin misuse, interactions, contraindications and side effects.Journal of experimental pharmacology · 2017Review
- Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models.Current neuropharmacology · 2016Review
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3 authors.
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Abstract
backgroundMefloquine can cross the blood-brain barrier and block the gap junction intercellular communication in the brain. Enhanced electrical coupling mediated by gap junctions is an underlying mechanism involved in the generation and maintenance of seizures. For this reason, the aim of this study was to analyze the effects of the systemic administration of mefloquine on tonic-clonic seizures induced by two acute models such as pentylenetetrazole and maximal electroshock.
resultsAll the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole. However, the incidence of seizures induced by pentylenetetrazole significantly decreased in the groups administered systematically with 40 and 80 mg/kg of mefloquine. In the control group, none of the rats survived after the generalized tonic-clonic seizures induced by pentylenetetrazole, but survival was improved by mefloquine. Besides, mefloquine significantly modified the total spectral power as well as the duration, amplitude and frequency of the epileptiform activity induced by pentylenetetrazole. For the maximal electroshock model, mefloquine did not change the occurrence of tonic hindlimb extension. However, this gap junction blocker significantly decreased the duration of the tonic hindlimb extension induced by the acute electroshock.
conclusionsThese data suggest that mefloquine at low doses might be eliciting some anticonvulsant effects when is systemically administered to rats.
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