Observational studyBMC urology2015
Urinary ATP as an indicator of infection and inflammation of the urinary tract in patients with lower urinary tract symptoms.
Observational study in BMC urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Urinary ATP may be a biomarker of interstitial cystitis/bladder pain syndrome and its severity.Biomolecules & biomedicine · 2024Article
- Super-Stable Metal-Organic Framework (MOF)/Luciferase Paper-Sensing Platform for Rapid ATP Detection.Biosensors · 2023Article
- Article
- Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner.Metabolites · 2022Article
- In Vivo Luminal Measurement of Distension-evoked Urothelial ATP Release in Rodents.Journal of visualized experiments : JoVE · 2022Article
- Applying Diagnostic Stewardship to Proactively Optimize the Management of Urinary Tract Infections.Antibiotics (Basel, Switzerland) · 2022Review
- A prospective observational study of urinary cytokines and inflammatory response in patients with Overactive Bladder Syndrome.BMC urology · 2021Observational
- LPS-mediated release of ATP from urothelial cells occurs by lysosomal exocytosis.Neurourology and urodynamics · 2020Article
- Urinary ATP may be a biomarker for bladder outlet obstruction and its severity in patients with benign prostatic hyperplasia.Translational andrology and urology · 2020Article
- Investigating the associations of mucosal P2Y6 receptor expression and urinary ATP and ADP concentrations, with symptoms of overactive bladder.Neurourology and urodynamics · 2020Article
- Biomarkers in urinary tract infections - which ones are suitable for diagnostics and follow-up?GMS infectious diseases · 2020Review
- Recalcitrant chronic bladder pain and recurrent cystitis but negative urinalysis: What should we do?International urogynecology journal · 2018Article
- Mass spectrometric measurement of urinary kynurenine-to-tryptophan ratio in children with and without urinary tract infection.Clinical biochemistry · 2018Article
- Urothelial cells may indicate underlying bacteriuria in pregnancy at term: a comparative study.BMC pregnancy and childbirth · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdenosine-5'-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary tract infection (UTI). The optimum clinical sampling method for ATP urinalysis has not been established. We tested the potential of urinary ATP in the assessment of lower urinary tract symptoms, infection and inflammation, and validated sampling methods for clinical practice.
methodsA prospective, blinded, cross-sectional observational study of adult patients presenting with lower urinary tract symptoms (LUTS) and asymptomatic controls, was conducted between October 2009 and October 2012. Urinary ATP was assayed by a luciferin-luciferase method, pyuria counted by microscopy of fresh unspun urine and symptoms assessed using validated questionnaires. The sample collection, storage and processing methods were also validated.
results75 controls and 340 patients with LUTS were grouped as without pyuria (n = 100), pyuria 1-9 wbc μl(-1) (n = 120) and pyuria ≥10 wbc μl(-1) (n = 120). Urinary ATP was higher in association with female gender, voiding symptoms, pyuria greater than 10 wbc μl(-1) and negative MSU culture. ROC curve analysis showed no evidence of diagnostic test potential. The urinary ATP signal decayed with storage at 23°C but was prevented by immediate freezing at ≤ -20°C, without boric acid preservative and without the need to centrifuge urine prior to freezing.
conclusionsUrinary ATP may have a role as a research tool but is unconvincing as a surrogate, clinical diagnostic marker.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.