Evidence map›Paper›PMID 25886927›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2015

Improving Adherence to Antiretroviral Therapy With Triggered Real-time Text Message Reminders: The China Adherence Through Technology Study.

Lora L Sabin, Mary Bachman DeSilva, Christopher J Gill, Li Zhong, Taryn Vian, Wubin Xie, Feng Cheng, Keyi Xu, Guanghua Lan, Jessica E Haberer and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03117842 (Using a Theory-based SMS/VM Intervention to Improve Sexual and Reproductive Health of Female Entertainment Workers in Cambodia), which is not on this map. Cited by 95 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03117842 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Using a Theory-based SMS/VM Intervention to Improve Sexual and Reproductive Health of Female Entertainment Workers in Cambodia: Study Protocol of a Randomized Controlled Trial

TypeinterventionalSponsorTouro University, CaliforniaRan2018 to 2019Enrolled600ConditionsReproductive Health, Sexual HealthArmsAutomated text and voice messages
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lora L Sabin*Center for Global Health and Development, Boston University, Boston, MA; †Department of Global Health, Boston University School of Public Health, Boston, MA; ‡FHI 360, Beijing, China; §Research Center for Public Health (TPHRC), School of Medicine, Tsinghua University, Beijing, China; ‖WHO Collaborating Center for Comprehensive Management of HIV Treatment and Care, Ditan Hospital, Beijing, China; ¶AIDS Division, Guangxi Centers for Disease Control and Prevention, Nanning, China; #Center for Global Health, Massachusetts General Hospital, Boston, MA; **Department of Health Policy and Management, Boston University School of Public Health, Boston, MA; and ††Edith Nourse Rogers Memorial VA Hospital, Bedford, MA.
Mary Bachman DeSilva
Christopher J Gill
Li Zhong
Taryn Vian
Wubin Xie
Feng Cheng
Keyi Xu
Guanghua Lan
Jessica E Haberer
David R Bangsberg
Yongzhen Li
Hongyan Lu
Allen L Gifford

Funding

China Adherence through Technology Study (CATS)R34DA032423 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SABIN, LORA L · 2012 to 2014
$670k
NIDA NIH HHS 1R34DA032423NIDA NIH HHS R34 DA032423
6 · The paper itself

Abstract

backgroundReal-time adherence monitoring is now possible through medication storage devices equipped with cellular technology. We assessed the effect of triggered cell phone reminders and counseling using objective adherence data on antiretroviral therapy (ART) adherence among Chinese HIV-infected patients.

methodsWe provided ART patients in Nanning, China, with a medication device (Wisepill) to monitor their ART adherence electronically. After 3 months, we randomized subjects within optimal (≥95%) and suboptimal (<95%) adherence strata to intervention vs. control arms. In months 4-9, intervention subjects received individualized reminders triggered by late dose taking (no device opening by 30 minutes past dose time) and counseling using device-generated data. Controls received no reminders or data-informed counseling. We compared postintervention proportions achieving optimal adherence, mean adherence, and clinical outcomes.

resultsOf 120 subjects enrolled, 116 (96.7%) completed the trial. Preintervention optimal adherence was similar in intervention vs. control arms (63.5% vs. 58.9%, respectively; P = 0.60). In the last intervention month, 87.3% vs. 51.8% achieved optimal adherence [risk ratio (RR): 1.7, 95% confidence interval (CI): 1.3 to 2.2] and mean adherence was 96.2% vs. 89.1% (P = 0.003). Among preintervention suboptimal adherers, 78.3% vs. 33.3% (RR: 2.4, CI: 1.2 to 4.5) achieved optimal adherence and mean adherence was 93.3% vs. 84.7% (P = 0.039). Proportions were 92.5% and 62.9% among optimal adherers, respectively (RR: 1.5, CI: 1.1 to 1.9) and mean adherence was 97.8% vs. 91.7% (P = 0.028). Postintervention clinical outcomes were not significant.

conclusionsReal-time reminders significantly improved ART adherence in this population. This approach seems promising for managing HIV and other chronic diseases and warrants further investigation and adaptation in other settings.

Indexed as

Medication AdherenceText MessagingAdultAnti-HIV AgentsChinaFemaleHIV InfectionsHumansMaleMiddle AgedAnti-HIV Agents

Identifiers

PMID25886927
PMCPMC4552400

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.