ArticleJournal of neurology, neurosurgery, and psychiatry2016
Retinal nerve fibre layer thinning is associated with drug resistance in epilepsy.
Article in Journal of neurology, neurosurgery, and psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07716930 (Retina-Based Biomarkers in Epilepsy), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Retina-Based Biomarkers in Epilepsy: Structural and Microvascular OCT Changes and Inflammatory Markers (sCD14, sCD163, CCL2, IL-1β) in Relation to Pathophysiology, Phenotype, Prognosis, and Drug-Resistant Epilepsy (DRE)
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Retinal nerve fiber layer thickness in epilepsy: a meta-analysis comparing affected patients with healthy controls.BMC ophthalmology · 2026Pooled it
- Fenfluramine Attenuates Retinal Microglial Activation but Does Not Rescue Structural and Vascular Deficits in a Rat Model of Dravet Syndrome.International journal of molecular sciences · 2026Article
- Analysing ocular structural morbidities in younger adults using anti-seizure drugs: a cross-sectional study.International ophthalmology · 2026Article
- Non-invasive screening of alzheimer's disease via label-free tri-spectral retinal imaging.Scientific reports · 2026Article
- Longitudinal evaluation of retinal neuroaxonal loss in epilepsy using optical coherence tomography.Epilepsia · 2024Article
- The thickness of the retinal nerve fiber layer, macula, and ganglion cell-inner plexiform layer in people with drug-resistant epilepsy.Epilepsia open · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Effects of sodium valproate and levetiracetam on posterior segment parameters in children with epilepsy.International ophthalmology · 2024Article
- Association between retinal thickness and disease characteristics in adult epilepsy: A cross-sectional OCT evaluation.Epilepsia open · 2024Article
- Choroid and Retinal Effects of Epilepsy and Epilepsy Subgroups.Beyoglu eye journal · 2024Article
- Evaluation of ganglion cell complex and retinal nerve fiber layer thinning in epilepsy patients.Indian journal of ophthalmology · 2023Article
- Reduction of Retinal Thickness Ipsilateral to Hippocampal Sclerosis in Epilepsy.Frontiers in neurology · 2021Article
- Study of Visual Function in Adult Epileptic Patients on Sodium Valproate or Carbamazepine Monotherapy.Cureus · 2019Article
- Observational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveRetinal nerve fibre layer (RNFL) thickness is related to the axonal anterior visual pathway and is considered a marker of overall white matter 'integrity'. We hypothesised that RNFL changes would occur in people with epilepsy, independently of vigabatrin exposure, and be related to clinical characteristics of epilepsy.
methodsThree hundred people with epilepsy attending specialist clinics and 90 healthy controls were included in this cross-sectional cohort study. RNFL imaging was performed using spectral-domain optical coherence tomography (OCT). Drug resistance was defined as failure of adequate trials of two antiepileptic drugs to achieve sustained seizure freedom.
resultsThe average RNFL thickness and the thickness of each of the 90° quadrants were significantly thinner in people with epilepsy than healthy controls (p<0.001, t test). In a multivariate logistic regression model, drug resistance was the only significant predictor of abnormal RNFL thinning (OR=2.09, 95% CI 1.09 to 4.01, p=0.03). Duration of epilepsy (coefficient -0.16, p=0.004) and presence of intellectual disability (coefficient -4.0, p=0.044) also showed a significant relationship with RNFL thinning in a multivariate linear regression model.
conclusionsOur results suggest that people with epilepsy with no previous exposure to vigabatrin have a significantly thinner RNFL than healthy participants. Drug resistance emerged as a significant independent predictor of RNFL borderline attenuation or abnormal thinning in a logistic regression model. As this is easily assessed by OCT, RNFL thickness might be used to better understand the mechanisms underlying drug resistance, and possibly severity. Longitudinal studies are needed to confirm our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.