ArticleGenome biology2015
Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice.Genetics · 2022Article
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It's complicated.Frontiers in immunology · 2022Review
- Sex differences in susceptibility to influenza A virus infection depend on host genotype.PloS one · 2022Article
- Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example.Journal of personalized medicine · 2021Review
- Evolution of genome structure in theGenome research · 2021Article
- Y chromosome copy number variation and its effects on fertility and other health factors: a review.Translational andrology and urology · 2021Review
- Article
- Consequences of Y chromosome microdeletions beyond male infertility.Journal of assisted reproduction and genetics · 2019Review
- Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines.Ecology and evolution · 2019Article
- Rethinking sex determination of non-gonadal tissues.Current topics in developmental biology · 2019Review
- Spermatogenesis and the Evolution of Mammalian Sex Chromosomes.Trends in genetics : TIG · 2018Review
- Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues.Proceedings. Biological sciences · 2017Article
- Sequence and Structural Diversity of Mouse Y Chromosomes.Molecular biology and evolution · 2017Article
- Modeling month-season of birth as a risk factor in mouse models of chronic disease: from multiple sclerosis to autoimmune encephalomyelitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Composite Regulatory Basis of the Large X-Effect in Mouse Speciation.Molecular biology and evolution · 2017Article
- Considering sex as a biological variable in preclinical research.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Review
- A time- and cost-effective strategy to sequence mammalian Y Chromosomes: an application to the de novo assembly of gorilla Y.Genome research · 2016Article
- Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease.PloS one · 2016Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe prevalence of some autoimmune diseases is greater in females compared with males, although disease severity is often greater in males. The reason for this sexual dimorphism is unknown, but it may reflect negative selection of Y chromosome-bearing sperm during spermatogenesis or male fetuses early in the course of conception/pregnancy. Previously, we showed that the sexual dimorphism in experimental autoimmune encephalomyelitis (EAE) is associated with copy number variation (CNV) in Y chromosome multicopy genes. Here, we test the hypothesis that CNV in Y chromosome multicopy genes influences the paternal parent-of-origin effect on EAE susceptibility in female mice.
resultsWe show that C57BL/6 J consomic strains of mice possessing an identical X chromosome and CNV in Y chromosome multicopy genes exhibit sperm head abnormalities and female-biased sex ratio. This is consistent with X-Y intragenomic conflict arising from an imbalance in CNV between homologous X:Y chromosome multicopy genes. These males also display paternal transmission of EAE to female offspring and differential loading of microRNAs within the sperm nucleus. Furthermore, in humans, families of probands with multiple sclerosis similarly exhibit a female-biased sex ratio, whereas families of probands affected with non-sexually dimorphic autoimmune diseases exhibit unbiased sex ratios.
conclusionsThese findings provide evidence for a mechanism at the level of the male gamete that contributes to the sexual dimorphism in EAE and paternal parent-of-origin effects in female mice, raising the possibility that a similar mechanism may contribute to the sexual dimorphism in multiple sclerosis.
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