ArticleBiology direct2015
An atlas of mouse CD4(+) T cell transcriptomes.
Article in Biology direct, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Meta-analysis of transcriptomic variation in T-cell populations reveals both variable and consistent signatures of gene expression and splicing.RNA (New York, N.Y.) · 2020Pooled it
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- Amplification cycles through innate lymphoid cells at the onset of lupus nephritis.Frontiers in immunology · 2026Article
- Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.NPJ Parkinson's disease · 2025Article
- Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model.Journal of diabetes and metabolic disorders · 2025Article
- Hippo Signaling Regulates High-NaCl-Induced Increase in RORγt+ Pro-Inflammatory Lymphocytes.International journal of molecular sciences · 2025Article
- Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy.Circulation research · 2025Article
- T cells use focal adhesions to pull themselves through confined environments.The Journal of cell biology · 2024Article
- The BulkECexplorer compiles endothelial bulk transcriptomes to predict functional versus leaky transcription.Nature cardiovascular research · 2024Article
- Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome.Journal of translational medicine · 2024Article
- Aberrant adaptive immune response underlies genetic susceptibility to tuberculosis.Frontiers in immunology · 2024Article
- IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.Science immunology · 2023Article
- T cells Use Focal Adhesions to Pull Themselves Through Confined Environments.bioRxiv : the preprint server for biology · 2023Article
- Distribution modeling quantifies collective TScience advances · 2023Article
- Inhibitory IL-10-producing CD4eLife · 2023Article
- Glioma immunotherapy enhancement and CD8-specific sialic acid cleavage by isocitrate dehydrogenase (IDH)-1.Oncogene · 2023Article
- IFNγ-induction of TNature immunology · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCD4(+) T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of several effector subtypes that exhibit distinct functions. The transcriptional mechanisms that underlie the specific functional identity of CD4(+) T cells are not fully understood.
resultsTo assist investigations into the transcriptional identity and regulatory processes of these cells we performed mRNA-sequencing on three murine T helper subtypes (Th1, Th2 and Th17) as well as on splenic Treg cells and induced Treg (iTreg) cells. Our integrated analysis of this dataset revealed the gene expression changes associated with these related but distinct cellular identities. Each cell subtype differentially expresses a wealth of 'subtype upregulated' genes, some of which are well known whilst others promise new insights into signalling processes and transcriptional regulation. We show that hundreds of genes are regulated purely by alternative splicing to extend our knowledge of the role of post-transcriptional regulation in cell differentiation.
conclusionsThis CD4(+) transcriptome atlas provides a valuable resource for the study of CD4(+) T cell populations. To facilitate its use by others, we have made the data available in an easily accessible online resource at www.th-express.org.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.