ArticleBMC evolutionary biology2015
Selection on MHC class II supertypes in the New Zealand endemic Hochstetter's frog.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Limited associations between MHC diversity and reproductive success in a bird species with biparental care.Ecology and evolution · 2024Article
- Conserved Evolution of MHC Supertypes among Japanese Frogs Suggests Selection for Bd Resistance.Animals : an open access journal from MDPI · 2023Article
- MHCtools - an R package for MHC high-throughput sequencing data: Genotyping, haplotype and supertype inference, and downstream genetic analyses in non-model organisms.Molecular ecology resources · 2022Article
- Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads,Conservation genetics (Print) · 2022Article
- Divergent and non-parallel evolution of MHC IIB in the Neotropical Midas cichlid species complex.BMC ecology and evolution · 2022Article
- Genetic diversity of toll-like receptor genes in the vulnerable Chinese egret (Egretta eulophotes).PloS one · 2020Article
- A high-density BAC physical map covering the entire MHC region of addax antelope genome.BMC genomics · 2019Article
- Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations.Immunogenetics · 2019Article
- Signatures of historical selection on MHC reveal different selection patterns in the moor frog (Rana arvalis).Immunogenetics · 2018Article
- Limited polymorphism of the functional MHC class II B gene in the black-spotted frog (Ecology and evolution · 2017Article
- Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen.Nature communications · 2017Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe New Zealand native frogs, family Leiopelmatidae, are among the most archaic in the world. Leiopelma hochstetteri (Hochstetter's frog) is a small, semi-aquatic frog with numerous, fragmented populations scattered across New Zealand's North Island. We characterized a major histocompatibility complex (MHC) class II B gene (DAB) in L. hochstetteri from a spleen transcriptome, and then compared its diversity to neutral microsatellite markers to assess the adaptive genetic diversity of five populations ("evolutionarily significant units", ESUs).
resultsL. hochstetteri possessed very high MHC diversity, with 74 DAB alleles characterized. Extremely high differentiation was observed at the DAB locus, with only two alleles shared between populations, a pattern that was not reflected in the microsatellites. Clustering analysis on putative peptide binding residues of the DAB alleles indicated four functional supertypes, all of which were represented in 4 of 5 populations, albeit at different frequencies. Otawa was an exception to these observations, with only two DAB alleles present.
conclusionsThis study of MHC diversity highlights extreme population differentiation at this functional locus. Supertype differentiation was high among populations, suggesting spatial and/or temporal variation in selection pressures. Low DAB diversity in Otawa may limit this population's adaptive potential to future pathogenic challenges.
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