ArticleAlzheimer disease and associated disorders
Trajectory of Mobility Decline by Type of Dementia.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- The Effects of Virtual Reality-Based Reminiscence Therapies for Older Adults With Cognitive Impairment: Systematic Review.Journal of medical Internet research · 2024Pooled it
- Driving and Alzheimer's dementia or mild cognitive impairment: a systematic review of the existing guidelines emphasizing on the neurologist's role.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.Journal of the American Medical Directors Association · 2016Pooled it
- When Walking Outlasts Cognition: Rethinking the Late-Stage of Lewy Body Dementia.Neuro-degenerative diseases · 2026Review
- Characterizing virtual community exercise programs for people with mobility limitations: a scoping review.Journal of exercise science and fitness · 2026Review
- Radar-Based Assessment of Sit-to-Stand Transitions as Digital Biomarkers of Pain and Physical Decline.Sensors (Basel, Switzerland) · 2026Article
- Gait, balance, and physical performance as markers of early Alzheimer's disease and related dementia risk.Journal of Alzheimer's disease : JAD · 2025Article
- Differences in physical function across dementia subtypes and cognitive decline: a cross-sectional study.European journal of translational myology · 2025Article
- Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study.International journal of geriatric psychiatry · 2025Article
- Reproducibility and validity of adapted clinical tests for the assessment of muscle strength in community-dwelling older adults living with Alzheimer's disease.BMC geriatrics · 2025Article
- Functional Recovery Predictors in Hip Fractures: Insights from a Community Clinical Pathway.Journal of clinical medicine · 2025Article
- ICAD: A Self-Supervised Autoregressive Approach for Multi-Context Anomaly Detection in Human Mobility Data.Proceedings of the ... ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems : ACM GIS. ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems · 2025Article
- Article
- Three-dimensional gait analysis in spinal disorders: biomechanical insights and clinical applications for diagnosis, surgical planning, and rehabilitation.Frontiers in neurology · 2025Review
- An Assessment of Physical Activity and Risk Factors in People Living with Dementia: Findings from a Cross-Sectional Study in a Long-Term Care Facility in Vietnam.Geriatrics (Basel, Switzerland) · 2024Article
- Cognitive Function Remains Associated With Functional Impairment in Profound Dementia: Alzheimer Disease and Dementia With Lewy Bodies.Neurology. Clinical practice · 2024Article
- Trajectories and influencing factors of cognitive function and physical disability in Chinese older people.Frontiers in public health · 2024Article
- Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer's Disease Model.Molecular neurobiology · 2023Article
- Dementia-related disability in the population aged 90 years and over: differences over time and the role of comorbidity in the vitality 90 + study.BMC geriatrics · 2023Article
- Is There a Sex-Frailty Paradox in Dementia?The journal of nutrition, health & aging · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Cognitive and physical aspects of functionality are closely related. However, whether physical decline differs by dementia type and progression rate is debatable. To address these issues, we conducted a longitudinal study of 766 older adults whose physical performance and cognitive status were assessed annually with standard assessment tools [eg, Physical Performance Test, Clinical Dementia Rate (CDR)] for 8 years. Compared with participants who remained cognitively normal, those progressing to later-stage dementia (CDR=1) declined in their mobility by a factor of 2.82 (P<0.001), followed by those who maintained a later-stage diagnosis (slope=-1.84, P<0.001), those progressing from early-stage to later-stage (CDR=0.5 to CDR=1) dementia (slope=-1.20, P<0.001), and those who progressed to early-stage dementia (slope=-0.39, P=0.038) suggesting a steeper physical decline with dementia progression, particularly in those with the fastest disease progression. Although all types of dementia experienced mobility decline, those progressing to non-Alzheimer disease (AD) dementias, especially vascular dementia declined faster than those who remained normal (slope=-2.70, P<0.001) or progressed to AD (slope=-2.18, P<0.001). These associations were better captured by the gait/balance component of physical functionality. Our findings suggest that rapidly progressing dementia patients particularly those with non-AD subtypes should be targeted for interventions to maintain or improve gait/balance and prevent functional decline and disability although AD patients may also benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.