ArticleBMC infectious diseases2015
Antifungal wound penetration of amphotericin and voriconazole in combat-related injuries: case report.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- New Challenges in the Diagnosis and Treatment of Primary Cutaneous Aspergillosis in Extensive Pediatric Burns.Journal of fungi (Basel, Switzerland) · 2025Article
- Continuous debridement combined with short-term posaconazole therapy for cutaneous mucormycosis caused byFrontiers in medicine · 2024Article
- [Research progress of mucormycosis in burns].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Social determinants of health as drivers of fungal disease.EClinicalMedicine · 2023Review
- Article
- Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B-Case Report.Antibiotics (Basel, Switzerland) · 2023Article
- Amphotericin B- and Levofloxacin-Loaded Chitosan Films for Potential Use in Antimicrobial Wound Dressings: Analytical Method Development and Its Application.Pharmaceutics · 2022Article
- Article
- Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis.Medical mycology case reports · 2021Article
- Article
- Designed Antimicrobial Peptides Against Trauma-Related Cutaneous Invasive Fungal Wound Infections.Journal of fungi (Basel, Switzerland) · 2020Article
- Article
- Combat trauma-related invasive fungal wound infections.Current fungal infection reports · 2020Article
- Mucormycosis in Burn Patients.Journal of fungi (Basel, Switzerland) · 2019Review
- Necrotizing fungal infection due toIndian journal of ophthalmology · 2018Review
- Drug delivery and tissue engineering to promote wound healing in the immunocompromised host: Current challenges and future directions.Advanced drug delivery reviews · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvivors of combat trauma can have long and challenging recoveries, which may be complicated by infection. Invasive fungal infections are a rare but serious complication with limited treatment options. Currently, aggressive surgical debridement is the standard of care, with antifungal agents used adjunctively with uncertain efficacy. Anecdotal evidence suggests that antifungal agents may be ineffective in the absence of surgical debridement, and studies have yet to correlate antifungal concentrations in plasma and wounds. CASE PRESENTATION: Here we report the systemic pharmacokinetics and wound effluent antifungal concentrations of five wounds from two male patients, aged 28 and 30 years old who sustained combat-related blast injuries in southern Afghanistan, with proven or possible invasive fungal infection. Our data demonstrate that while voriconazole sufficiently penetrated the wound resulting in detectable effluent levels, free amphotericin B (unbound to plasma) was not present in wound effluent despite sufficient concentrations in circulating plasma. In addition, considerable between-patient and within-patient variability was observed in antifungal pharmacokinetic parameters.
conclusionThese data highlight the need for further studies evaluating wound penetration of commonly used antifungals and the role for therapeutic drug monitoring in providing optimal care for critically ill and injured war fighters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.