Evidence map›Paper›PMID 25886536›Full record

Trial reportBMC research notes2015

Effects of chewing gum against postoperative ileus after pancreaticoduodenectomy--a randomized controlled trial.

Thomas Andersson, Kristofer Bjerså, Kristin Falk, Monika Fagevik Olsén

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02319512 (Effects of Chewing Gum Against Postoperative Ileus After Pancreaticoduodenectomy - a Randomized Controlled Trial), which is not on this map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02319512 phase3terminatednot on this map

Effects of Chewing Gum Against Postoperative Ileus After Pancreaticoduodenectomy - a Randomized Controlled Trial

TypeinterventionalSponsorThomas AnderssonRan2012 to 2013Enrolled65ConditionsPostoperative IleusArmsChewing gum, Glucose
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Postoperative nutritional support after pancreaticoduodenectomy in adults.The Cochrane database of systematic reviews · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Thomas AnderssonDepartment of Surgery, Sahlgrenska University Hospital, Gothenburg, S-41345, Sweden. thomas.k.andersson@vgregion.se.
Kristofer BjersåDivision of Nursing Science, Department of Medical and Health Sciences, University of Linköping, Linköping, Sweden. kristofer.bjersa@liu.se.
Kristin FalkInstitute of Health and Care Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden. kristin.falk@fhs.gu.se.
Monika Fagevik OlsénDepartment of Surgery, Sahlgrenska University Hospital, Gothenburg, S-41345, Sweden. monika.fagevik-olsen@vgregion.se.
Sahlgrenska University Hospital · SELinköping University · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative ileus is common after surgery. One non-pharmacological intervention that has shown promising results in reducing the duration of postoperative ileus is chewing gum after surgery. However, this has not been investigated in upper gastrointestinal surgery such as pancreatic surgery. Hence the aim of this study was to investigate the effects of chewing gum treatment on patients undergoing pancreaticoduodenectomy ad modum whipple due to pancreatic or periampullary cancer.

methodsThis study was conducted as a phase III trial that was terminated early. Patients diagnosed with pancreatic tumours scheduled for pancreaticoduodenectomy ad modum whipple were included. The treatment group received chewing gum postoperatively and standard care. Controls received glucose solution and standard care. Chewing gum and glucose were used four times a day during the whole hospital stay. Time to first flatus and stool was defined as the primary outcome. The secondary outcome was start with clear liquids, start with liquid diet and length of hospital stay.

resultsNo statistically significant differences could be observed between the chewing gum intervention group and the control group. However, a numerical difference in mean time was observed in first flatus, first stool, start of clear fluids, and start of liquid diet and length of hospital stay in favour of the intervention group.

conclusionsAlthough this study did not find statistically significant differences favouring the use of chewing gum for postoperative ileus, a positive trend was observed of a reduction of the impact of postoperative ileus among patients after pancreatic surgery. It also contributes valuable methodological experience that is important for future studies of chewing gum interventions during recovery after pancreatic surgery.

trial registrationClinicalTrials.gov identifier: NCT02319512 , publication date 2014-12-17.

Indexed as

Chewing GumDietary SupplementsPancreaticoduodenectomyPostoperative ComplicationsAgedAmpulla of VaterCommon Bile Duct NeoplasmsDefecationFemaleHumansIleusLength of StayMaleMiddle AgedPancreasPancreatic NeoplasmsChewing Gum

Identifiers

PMID25886536
PMCPMC4331300
OpenAlexW1963967209

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.