Evidence map›Paper›PMID 25886491›Full record

ArticleVirology journal2015

Polyclonal gammopathy after BKV infection in HSCT recipient: a novel trigger for plasma cells replication?

Natalia Maximova, Antonio Pizzol, Aurelio Sonzogni, Massimo Gregori, Marilena Granzotto, Paolo Tamaro

Open access · goldAbstract readCase Reports
In one paragraph

Article in Virology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Native kidney BK virus nephropathy, a systematic review.Transplant infectious disease : an official journal of the Transplantation Society · 2019
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Natalia MaximovaBone Marrow Transplant Unit, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria 65/1, 34134, Trieste, Italy. natalia.maximova@burlo.trieste.it.
Antonio PizzolPediatric Hemato-Oncology Department, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. pizzol.antonio@gmail.com.
Aurelio SonzogniDepartment of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy. asonzogni@hpg23.it.
Massimo GregoriDepartment of Radiology, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. massimo.gregori@burlo.trieste.it.
Marilena GranzottoLaboratory Department, A.O.U. Ospedali Riuniti, Trieste, Italy. marilena.granzotto@gmail.com.
Paolo TamaroPediatric Hemato-Oncology Department, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. paolo.tamaro@burlo.trieste.it.
IRCCS Materno Infantile Burlo Garofolo · ITAzienda Ospedaliero Universitaria Ospedali Riuniti · ITOspedale Papa Giovanni XXIII · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBK polyomavirus infects most of the general population. However, its clinical manifestations are almost exclusively seen in immunocompromised patients, particularly in kidney and hematopoietic stem cell transplantation recipients. CASE PRESENTATION: A 15-y-old female suffering from common B-cell acute lymphoblastic leukaemia underwent hematopoietic stem cell transplantation. The patient had reactivation of BKPyV infection and developed an haemorrhagic cystitis. Three months after transplant, BKPyV viremia and viruria increased and she developed a severe nephropathy associated to a polyclonal gammopathy with high levels of isolated IgM.

conclusionThis case report describes a rare and unexpected polyclonal gammopathy developed during a polyomavirus-associated nephropathy confirmed by immunohistochemical and laboratory analyses.

Indexed as

AdolescentAntibodies, ViralBK VirusFemaleHematopoietic Stem Cell TransplantationHumansKidney DiseasesLeukemia, B-CellPlasma CellsPolyomavirus InfectionsPrecursor Cell Lymphoblastic Leukemia-LymphomaAntibodies, Viral

Identifiers

PMID25886491
PMCPMC4335512
OpenAlexW2107333865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.