ArticleBMC cancer2015
Local control in metastatic neuroblastoma in children over 1 year of age.
Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Roles of Surgery in the Treatment of Patients With High-Risk Neuroblastoma in the Children Oncology Group Study: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Dose-escalation is needed for gross disease in high-risk neuroblastoma.Pediatric blood & cancer · 2018Trial
- Impact of radiotherapy on survival outcomes in metastatic neuroblastoma a propensity score matched SEER database analysis.Scientific reports · 2025Article
- Treatment and outcomes of high-risk neuroblastoma in Southeast Asia: a single-institution experience and review of the literature.Singapore medical journal · 2023Review
- Article
- International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines.Ecancermedicalscience · 2022Article
- Dosimetric comparison of tomotherapy and volumetric-modulated arc therapy for children with neuroblastoma.Pediatric investigation · 2020Article
- Prospective Evaluation of Radiation Dose Escalation in Patients With High-Risk Neuroblastoma and Gross Residual Disease After Surgery: A Report From the Children's Oncology Group ANBL0532 Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Article
- Advances in the Surgical Treatment of Neuroblastoma.Chinese medical journal · 2018Review
- Article
- Impact of Extent of Resection on Local Control and Survival in Patients From the COG A3973 Study With High-Risk Neuroblastoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Article
- Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma.International journal of radiation oncology, biology, physics · 2016Article
- SPARC overexpression combined with radiation retards angiogenesis by suppressing VEGF-A via miR‑410 in human neuroblastoma cells.International journal of oncology · 2016Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLocal control is always considered in metastatic neuroblastoma (NBL). The aim of this study is to evaluate the impact of radical surgery on survival in children over 1 year of age.
methodsFifty-eight patients older than 1 year of age with metastatic NBL were treated with conventional plus high-dose chemotherapy with or without addition of local radiotherapy (RT, 21Gy). Surgery was classified as radical surgery (complete resection and gross total resection) or non-radical surgery. The Kaplan-Meier method and the Cox proportional hazard model were used to calculate the probability of progression free and overall survival (PFS and OS) and for multivariate analysis.
resultsThe 5-year PFS and OS for patients with radical surgery were 26% (95% CI 14-40%) and 38% (95% CI 23-53%) respectively, while the PFS and OS for patients without radical surgery were 33% (95% CI 10-59%) and 31% (95% CI 10-55%) (respectively, P 0.85 and P 0.42). The 5-year PFS and OS for patients who received RT were 36% (95% CI 19-53%) and 46% (95% CI 26-64%) respectively, while the 5-year PFS and OS for patients who did not receive RT were 22% (95% CI 9-38%) and 27% (95% CI 13-42%) respectively (P 0.02 for PFS). Multivariate analysis confirmed the role of well-known prognostic factors, such as the presence of MYCN amplification, age and response before high-dose chemotherapy.
conclusionsOur data suggest that the degree of resection does not influence survival in metastatic NBL patients treated with high-dose chemotherapy; local RT contributes to local disease control.
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