ArticleWorld journal of surgical oncology2015
Impact of tumor size on subclinical central lymph node metastasis in papillary thyroid microcarcinoma depends on age.
Article in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The incidence and risk factors for central lymph node metastasis in cN0 papillary thyroid microcarcinoma: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- The necessity of prophylactic central lymph node dissection in clinically n0 papillary thyroid carcinoma: perspective from the endemic region.Langenbeck's archives of surgery · 2025Observational
- The effect of central lymph node dissection on the prognosis of cN0 papillary thyroid microcarcinoma: a mid-term follow-up study.BMC endocrine disorders · 2023Article
- Clinical and ultrasonographic features of medullary thyroid microcarcinomas compared with papillary thyroid microcarcinomas: a retrospective analysis.BMC medical imaging · 2020Article
- Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study.BMC cancer · 2020Article
- Predictive Factors of Central-Compartment Lymph Node Metastasis for Clinical N0 Papillary Thyroid Carcinoma With Strap Muscle Invasion.Frontiers in endocrinology · 2020Article
- Which papillary thyroid microcarcinoma should be treated as "true cancer" and which as "precancer"?World journal of surgical oncology · 2019Article
- Clinicopathological characteristics and recurrence risk of papillary thyroid microcarcinoma in the elderly.Cancer management and research · 2019Article
- Retrospective analysis of prognostic factors in patients of papillary thyroid microcarcinoma.Oncotarget · 2018Article
- Relationships between clinicopathological prognostic factors in papillary thyroid microcarcinoma: a refined analysis based on 428 cases.International journal of clinical and experimental pathology · 2017Article
- The analysis of clinicopathologic predictors of lymph node metastasis and postoperative recurrence in patients with papillary thyroid microcarcinoma from Guangdong Province, China-a multicenter retrospective study.International journal of clinical and experimental pathology · 2017Article
- Incidental and non-incidental thyroid microcarcinoma.Oncology letters · 2016Article
- Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area.Journal of thyroid research · 2016Article
- To Identify Predictors of Central Lymph Node Metastasis in Patients with Clinically Node-Negative Conventional Papillary Thyroid Carcinoma.International journal of endocrinology · 2016Article
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10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to evaluate whether the associations between clinicopathologic factors of papillary thyroid microcarcinoma (PTMC), especially tumor size, and subclinical central lymph node metastasis (LNM) are dependent on patient age.
methodsThe medical records of 428 patients who underwent thyroid surgery for PTC measuring ≤1 cm were reviewed. All patients were clinically lymph node negative and underwent thyroidectomy with unilateral or bilateral central lymph node dissection. Univariate and multivariate analyses were performed to identify clinicopathologic factors associated with central LNM.
resultsCentral LNM was identified in 96 of 428 (22.4%) patients. Mean tumor size was significantly greater in patients with than without central LNM (0.74 ± 0.22 cm vs. 0.64 ± 0.23 cm, P = 0.001). Tumor size > 0.5 cm was significantly predictive of central LNM. Subgroup analysis according to age groups showed that tumor size was an independent predictor of subclinical central LNM only in patients aged ≥45 years.
conclusionsFactors predictive of central LNM in patients with PTMC differed by age. PTMC size was an independent predictor of subclinical central LNM only in patients aged ≥45 years.
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