ArticleGenome biology2015
Detecting non-allelic homologous recombination from high-throughput sequencing data.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
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- Recombination events restored the functional horned haplotypes in the offspring of polled parents.Genetics, selection, evolution : GSE · 2025Article
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- The rate and spectrum of new mutations in mice inferred by long-read sequencing.Genome research · 2025Article
- Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy.Orphanet journal of rare diseases · 2025Article
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- A graph clustering algorithm for detection and genotyping of structural variants from long reads.GigaScience · 2024Article
- Most large structural variants in cancer genomes can be detected without long reads.Nature genetics · 2023Article
- Oncogenic structural aberration landscape in gastric cancer genomes.Nature communications · 2023Article
- Rates and spectra of de novo structural mutations inGenome research · 2023Article
- A Novel FrameshiftBiomedicines · 2022Article
- African Suid Genomes Provide Insights into the Local Adaptation to Diverse African Environments.Molecular biology and evolution · 2022Article
- Review
- Repeated translocation of a supergene underlying rapid sex chromosome turnover inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- CRISPR/Cas9-induced gene conversion betweenHGG advances · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Non-allelic homologous recombination (NAHR) is a common mechanism for generating genome rearrangements and is implicated in numerous genetic disorders, but its detection in high-throughput sequencing data poses a serious challenge. We present a probabilistic model of NAHR and demonstrate its ability to find NAHR in low-coverage sequencing data from 44 individuals. We identify NAHR-mediated deletions or duplications in 109 of 324 potential NAHR loci in at least one of the individuals. These calls segregate by ancestry, are more common in closely spaced repeats, often result in duplicated genes or pseudogenes, and affect highly studied genes such as GBA and CYP2E1.
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