Evidence map›Paper›PMID 25885912›Full record

ArticleWorld journal of surgical oncology2015

Predictors of early recurrence after resection of colorectal liver metastases.

Ricky Harminder Bhogal, James Hodson, Simon Roderick Bramhall, John Isaac, Ravi Marudanayagam, Darius Feroze Mirza, Paolo Muiesan, Robert Peter Sutcliffe

Abstract read
In one paragraph

Article in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Early Recurrence of Neuroendocrine Liver Metastasis After Curative Hepatectomy: Risk Factors, Prognosis, and Treatment.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ricky Harminder BhogalUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. balsin@hotmail.com.
James HodsonUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. j.hodson@uhb.nhs.uk.
Simon Roderick BramhallUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. s.bramhall@uhb.nhs.uk.
John IsaacUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. j.isaac@uhb.nhs.uk.
Ravi MarudanayagamUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. r.marudanayagam@uhb.nhs.uk.
Darius Feroze MirzaUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. d.f.mirza@uhb.nhs.uk.
Paolo MuiesanUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. p.muiesan@uhb.nhs.uk.
Robert Peter SutcliffeUniversity Hospitals of Birmingham, Metchley Lane, Birmingham, West Midlands, B15 2TT, UK. robert.sutcliffe@uhb.nhs.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly recurrence after resection of colorectal liver metastases (CLM) is common. Patients at risk of early recurrence may be candidates for enhanced preoperative staging and/or earlier postoperative imaging. The aim of this study was to determine if there are any risk factors that specifically predict early liver-only and systemic recurrence.

methodsRetrospective analysis of prospective database of patients undergoing liver resection (LR) for CLM from 2004 to 2006 was undertaken. Early recurrence was defined as occurring within 18 months of LR. Patients were classified into three groups: early liver-only recurrence, early systemic recurrence and recurrence-free. Preoperative factors were compared between patients with and without early recurrence.

resultsTwo hundred and forty-three consecutive patients underwent LR for CLM. Twenty-seven patients (11%) developed early liver-only recurrence. Dukes C stage and male sex were significantly associated with early liver-only recurrence (P < 0.05). Sixty-six patients (27%) developed early systemic recurrence. Tumour size ≥3.6 cm and tumour number (>2) were significantly associated with early systemic recurrence (P < 0.001).

conclusionsIt is possible to stratify patients according to the risk of early liver-only or systemic recurrence after resection of CLM. High-risk patients may be candidates for preoperative MRI and/or computed tomography-positron emission tomography (CT-PET) scan and should receive intensive postoperative surveillance.

Indexed as

AgedColorectal NeoplasmsFemaleFollow-Up StudiesHepatectomyHumansLiver NeoplasmsMaleNeoplasm Recurrence, LocalNeoplasm StagingPrognosisProspective StudiesRetrospective StudiesRisk Factors

Identifiers

PMID25885912
PMCPMC4389659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.