ArticlePloS one2015
Weaker dental enamel explains dental decay.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of immediate and delayed composite restoration on shear bond strength to remineralized initial enamel lesions: an in vitro study.The Saudi dental journal · 2026Article
- AMELX gene association to early childhood caries in south-Indian children: a case-control study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Elucidating the role of keratin 75 in enamel using Krt75Frontiers in physiology · 2022Article
- Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries.Frontiers in dental medicine · 2022Article
- Identification of oral symptoms associated with atopic dermatitis in adolescents: Results from the Korea national representative survey 2009-2017.Scientific reports · 2020Article
- When to intervene in the caries process? A Delphi consensus statement.British dental journal · 2020Article
- Measuring the Microscopic Structures of Human Dental Enamel Can Predict Caries Experience.Journal of personalized medicine · 2020Article
- When to intervene in the caries process? An expert Delphi consensus statement.Clinical oral investigations · 2019Article
- Are the mutans streptococci still considered relevant to understanding the microbial etiology of dental caries?BMC oral health · 2018Article
- Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children.Clinical oral investigations · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors. In order to test the hypothesis that amount of amelogenin during enamel development can influence caries susceptibility, we generated multiple strains of mice with varying levels of available amelogenin during dental development. Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.