ArticleThe European journal of neuroscience2015
Role of vasoactive intestinal peptide in the light input to the circadian system.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Evolutionary and physiological arguments for the existence of a circalunar clock in humans.BMC ecology and evolution · 2026Review
- Heterogeneity between VIP and GRP neurons underlies AVP receptor signaling in the mouse suprachiasmatic nucleus.Communications biology · 2026Article
- Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting.Neuroscience bulletin · 2025Article
- Pigment-dispersing factor neuropeptides act as multifunctional hormones and modulators in tardigrades.Open biology · 2025Article
- Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNCommunications biology · 2024Article
- Hepatocellular Carcinoma in Mice Affects Neuronal Activity and Glia Cells in the Suprachiasmatic Nucleus.Biomedicines · 2024Article
- Suprachiasmatic nucleus VIPergic fibers show a circadian rhythm of expansion and retraction.Current biology : CB · 2024Article
- Immediate responses to ambient lightiScience · 2023Article
- In vivo recording of the circadian calcium rhythm in Prokineticin 2 neurons of the suprachiasmatic nucleus.Scientific reports · 2023Article
- In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting.PLoS biology · 2023Article
- Phenotyping of light-activated neurons in the mouse SCN based on the expression of FOS and EGR1.Frontiers in physiology · 2023Article
- Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice.Frontiers in physiology · 2022Article
- Cell Type-Specific Genetic Manipulation and Impaired Circadian Rhythms inFrontiers in physiology · 2022Article
- Reviewing Evidence for the Relationship of EEG Abnormalities and RTT Phenotype Paralleled by Insights from Animal Studies.International journal of molecular sciences · 2021Review
- Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States.Frontiers in neurology · 2021Review
- Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens.BMC ophthalmology · 2019Article
- Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.Nature communications · 2019Article
- SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of the Circadian System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Functional Peptidomics: Stimulus- and Time-of-Day-Specific Peptide Release in the Mammalian Circadian Clock.ACS chemical neuroscience · 2018Article
- Resynchronization Dynamics Reveal that the Ventral Entrains the Dorsal Suprachiasmatic Nucleus.Journal of biological rhythms · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
The neuropeptide vasoactive intestinal peptide (VIP) is expressed at high levels in a subset of neurons in the ventral region of the suprachiasmatic nucleus (SCN). While VIP is known to be important for the synchronization of the SCN network, the role of VIP in photic regulation of the circadian system has received less attention. In the present study, we found that the light-evoked increase in electrical activity in vivo was unaltered by the loss of VIP. In the absence of VIP, the ventral SCN still exhibited N-methyl-d-aspartate-evoked responses in a brain slice preparation, although the absolute levels of neural activity before and after treatment were significantly reduced. Next, we used calcium imaging techniques to determine if the loss of VIP altered the calcium influx due to retinohypothalamic tract stimulation. The magnitude of the evoked calcium influx was not reduced in the ventral SCN, but did decline in the dorsal SCN regions. We examined the time course of the photic induction of Period1 in the SCN using in situ hybridization in VIP-mutant mice. We found that the initial induction of Period1 was not reduced by the loss of this signaling peptide. However, the sustained increase in Period1 expression (after 30 min) was significantly reduced. Similar results were found by measuring the light induction of cFOS in the SCN. These findings suggest that VIP is critical for longer-term changes within the SCN circuit, but does not play a role in the acute light response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.