Evidence map›Paper›PMID 25885634›Full record

Trial reportBMC cancer2015

Factors influencing participation in a randomized controlled resistance exercise intervention study in breast cancer patients during radiotherapy.

Sandra M Gollhofer, Joachim Wiskemann, Martina E Schmidt, Oliver Klassen, Cornelia M Ulrich, Jan Oelmann, Holger Hof, Karin Potthoff, Karen Steindorf

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01468766 (Effects of a Supervised Progressive Resistance Training With Breast Cancer Patients During Adjuvant Radiotherapy - A Randomised Controlled Intervention Trial), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01468766 nacompletednot on this map

Effects of a Supervised Progressive Resistance Training With Breast Cancer Patients During Adjuvant Radiotherapy - A Randomised Controlled Intervention Trial

TypeinterventionalSponsorGerman Cancer Research CenterRan2011 to 2014Enrolled160ConditionsBreast Cancer, Cancer-related FatigueArmsSupervised progressive resistance training, Supervised progressive muscle relaxation training (Jacobson method)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024
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  9. The effectiveness of exercise and/or nutritional interventions to improve the quality of life of women with breast cancer receiving radiation therapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  17. The association between fatigue and pain symptoms and decreased physical activity after cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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  18. Predictors of enrollment in individual- and couple-based lifestyle intervention trials for cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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  19. Patient-reported physical activity and the association with health-related quality of life in head and neck cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sandra M GollhoferUnit of Physical Activity and Cancer, Department of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. sandragollhofer@yahoo.de.
Joachim WiskemannUnit of Physical Activity and Cancer, Department of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. joachim.wiskemann@nct-heidelberg.de.
Martina E SchmidtUnit of Physical Activity and Cancer, Department of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. m.schmidt@dkfz-heidelberg.de.
Oliver KlassenUnit of Physical Activity and Cancer, Department of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. oliver.klassen@nct-heidelberg.de.
Cornelia M UlrichDepartment of Preventive Oncology, National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. neli.ulrich@hci.utah.edu.
Jan OelmannDepartment of Radiation Oncology, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. jan.oelmann@med.uni-heidelberg.de.
Holger HofDepartment of Radiation Oncology, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. hof@strahlentherapie-neustadt.de.
Karin PotthoffDepartment of Medical Oncology, National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. karin.potthoff@med.uni-heidelberg.de.
Karen SteindorfUnit of Physical Activity and Cancer, Department of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. k.steindorf@dkfz-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the past years knowledge about benefits of physical activity after cancer is evolving from randomized exercise intervention trials. However, it has been argued that results may be biased by selective participation. Therefore, we investigated factors influencing participation in a randomized exercise intervention trial for breast cancer patients.

methodsNon-metastatic breast cancer patients were systematically screened for a randomized exercise intervention trial on cancer-related fatigue. Participants and nonparticipants were compared concerning sociodemographic characteristics (age, marital status, living status, travel time to the training facility), clinical data (body-mass-index, tumor stage, tumor size and lymph node status, comorbidities, chemotherapy), fatigue, and physical activity. Reasons for participation or declination were recorded.

results117 patients (52 participants, 65 nonparticipants) were evaluable for analysis. Multiple regression analyses revealed significantly higher odds to decline participation among patients with longer travel time (p=0.0012), living alone (p=0.039), with more comorbidities (0.031), previous chemotherapy (p=0.0066), of age≥70 years (p=0.025), or being free of fatigue (p=0.0007). No associations were found with BMI or physical activity. By far the most frequently reported reason for declination of participation was too long commuting time to the training facility.

conclusionsWillingness of breast cancer patients to participate in a randomized exercise intervention study differed by sociodemographic factors and health status. Neither current physical activity level nor BMI appeared to be selective for participation. Reduction of personal inconveniences and time effort, e.g. by decentralized training facilities or flexible training schedules, seem most promising for enhancing participation in exercise intervention trials.

trial registrationRegistered at ClinicalTrials.gov: NCT01468766 (October 2011).

Indexed as

Exercise TherapyPatient Acceptance of Health CareTransportationAdultAgedAge FactorsAntineoplastic AgentsBreast NeoplasmsComorbidityFatigueFemaleHealth StatusHumansMiddle AgedResidence CharacteristicsTime FactorsAntineoplastic Agents

Identifiers

PMID25885634
PMCPMC4466838

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.